张志滨?傅春恋?郭轶

[摘要] 目的 探析维持性精神分裂症在奥氮平治疗下的临床效果。 方法 选取2015年1月～2016年1月于我院接受治疗的60例维持性精神分裂症的患者，所有患者按照随机数字表法均分为两组（对照组与观察组），其中对照组予以氯氮平治疗，观察组予以奥氮平治疗，比较两组患者在不同治疗方法下的临床效果（治疗前后的精神症状评分、PANSS评分（阳性与阴性症状量表评分）、不良反应发生情况）。 结果 两组患者治疗后的精神症状评分均较治疗前低，且其差异具有统计学意义（P<0.05），但是两组治疗后的组间差异不存在统计学意义（P>0.05）；两组患者治疗后的PANSS评分亦较治疗前低，且其差异具有统计学意义（P<0.05），但是两组治疗后的组间差异不存在统计学意义（P>0.05）；对照组的不良反应发生率（33.33%）较观察组（10.00%）高，且其差异具有统计学意义（P<0.05）。 结论 对维持性精神分裂症患者而言，予用奥氮平进行治疗不仅具有较佳的临床效果，且具有可观的安全性，因而值得推广应用。

[关键词] 维持性精神分裂症；奥氮平；治疗效果；PANSS评分

[中图分类号] R479.3 [文献标识码] A [文章编号] 2095-0616（2017）16-32-03

Clinical effect of olanzapine in treatment of maintaining schizophrenia

ZHANG Zhibin FU Chunlian GUO Yi

Guangzhou Civil Affairs Bureau Mental Hospital，Guangzhou 510430，China

[Abstract] Objective To explore and analyze clinical effect of olanzapine in treatment of maintaining schizophrenia. Methods 60 patients with maintaining schizophrenia who were treated in our hospital from January 2015 to January 2016 were analyzed. According to random number table，they were divided into two groups （the control group and the observation group）.The control group was given clozapine while the observation group was given olanzapine.Clinical effects of different methods （psychiatric symptom scores before and after treatment），PANSS score （Positive and Negative Syndrome Scale） and adverse reactions of patients in two groups were compared and analyzed. Results Psychiatric symptom scores after treatment of patients in two groups were all lower than those before treatment.The difference was statistically significant（P<0.05）.After treatment，difference between two groups had no statistical significance （P>0.05）.PANSS score after treatment of patients in two groups was also lower than that before treatment.The difference was statistically significant（P<0.05）.After treatment，difference between two groups had no statistical significance（P>0.05）.Rate of adverse reactions in the control group was 33.33%，higher than that in the observation group（10.00%）.The difference was statistically significant（P<0.05）. Conclusion Olanzapine in treatment of patients with maintaining schizophrenia not only has better clinical effect，but also has good safety，which is worthy of promotion and application.

[Key words] Maintaining schizophrenia；Olanzapine；Treatment effect；PANSS score

精神分裂癥是一种基于个性、情感、思维、行为等分裂的精神科疾病，具有慢性发展、反复发作等特点，多发于青壮年人群[1]。精神分裂症的主要征兆被认为是基本的思考结构与认知能力发生破裂，因而极大程度上会出现精神活动与环境不协调的行为，进而可能会对社会与家庭带来较为严重的影响；由此可见，对该类病症患者进行早期、积极地治疗及干预尤为重要且迫切[2]。但是基于对治疗安全性与高效性的考虑，临床上应尽量选用便于长期使用、作用性广泛、不良反应作用性低的药物[3]。奥氮平是我国目前针对抗精神病的新型药物之一，其临床的作用性与安全性一直得到认可，因而具有进一步展开探究的价值，因此本研究旨在前人的研究基础上进一步分析这一药物在维持性精神分裂症治疗中的作用性，现报道如下。endprint