于鹏

[摘要] 目的 观察硫辛酸注射液对甲基苯丙胺依赖者脑损伤的临床疗效。 方法 对2014年7月～2015年2月收治的男性甲基苯丙胺滥用者72例随机分成观察组和对照组各36例，两组均给予心理治疗及对症治疗，观察组患者实行硫辛酸注射液治疗，对照组患者采取注射用还原型谷胱甘肽治疗，21d为 1个疗程，停药后比较两组治疗效果。 结果 治疗后，从戒断症状比较看，观察组总有效率为94.4%，对照组总有效率为75.0%，观察组总有效率高于对照组，差异有统计学意义（χ2=3.863，P=0.049）。治疗后，两组的MoCA量表评分均比治疗前有改善，且观察组改善幅度优于对照组，差异均有统计学意义（P<0.05）。 结论 硫辛酸注射液治疗甲基苯丙胺依赖者脑损伤具有明显的临床疗效。

[关键词] 甲基苯丙胺类滥用者；脑损伤；硫辛酸注射液；注射用还原型谷胱甘肽

[中图分类号] R651.15 [文献标识码] A [文章编号] 2095-0616（2017）16-29-04

Clinical curative effect observation of thioctic acid injection in the treatment of brain damage caused by methamphetamine

YU Peng

Shandong Province Shandong Forced Isolation Treatment， Shandong， Zibo 255311， China

[Abstract] Objective To observe the clinical curative effect of Thioctic Acid Injection in the treatment of brain damage caused by methamphetamine. Methods 72 cases of male methamphetamine abusers from July 2014 to February 2015 were randomly divided into observation group and control group with 36 cases in each. All the patients were given psychological treatment and symptomatic treatment. Patients in observation group were treated with Thioctic Acid Injection， and patients in control group were treated with Reduced Glutathione for Injection， 21d for 1 courses. After withdrawal， treatment effects of the two groups were compared. Results After treatment， compared with withdrawal symptoms， the total effective rate of the observation group was 94.4%， and that of the control group was 75%. The total effective rate of the observation group was higher than that of the control group， the difference was statistically significant （χ2=3.863， P=0.049）. After treatment， the MoCA scale scores of the two groups were better than those before treatment， and the improvement rate of the observation group was better than that of the control group， the difference was statistically significant （P<0.05）. Conclusion Thioctic Acid Injection has obvious clinical efficacy in the treatment of brain damage caused by methamphetamine.

[Key words] The class of methamphetamine abusers； Brain injury； Thioctic Acid Injection； Reduced Glutathione for injection

进入21世纪，以甲基苯丙胺（冰毒）为代表的新型合成毒品已成为我国滥用最为广泛、蔓延最为迅速的毒品。据《2015年中国毒品形势报告》反映，2015年全国共查处吸毒人员106.2萬人次，在新发现的吸毒人员53.1万名中，滥用冰毒等苯丙胺人员占73.2%[1]。甲基苯丙胺脂溶性高，易通过血脑屏障，破坏神经元细胞内氧化还原平衡，导致氧化应激，产生大量自由基，造成神经细胞DNA 损伤[2]，最终损伤脑结构，导致脑功能异常。在临床实践中我们发现，甲基苯丙胺成瘾者可以出现注意力不能集中、记忆力下降、表达能力下降、逻辑思维能力差等认知功能轻度损害情况，严重者导致幻觉、妄想、甚至苯丙胺精神病，严重危害家庭及社会公共安全[3]。……