李龙?武晓萌?袁秀梅?魏威

[摘要] 目的 探究西格列汀和伏格列波糖分别联合实时动态胰岛素泵对于治疗初发T2DM患者的临床效果。方法 选取2013年1月～2015年12月于我院接受治疗的104例初发2型糖尿病者为研究对象，按照随机数表法将患者平均分为两组，每组各52例。两组患者均进行糖尿病的基础治疗，对照组在此基础上加以伏格列波糖聯合实时动态胰岛素泵进行治疗，实验组加以西格列汀联合实时动态胰岛素泵进行治疗。治疗4周后比较两组患者多项指标。结果 对血糖指标进行检测实验组患者血糖指标与对照组患者相比具有统计学差异，实验组患者血糖水平、空腹血糖值、餐后2h血糖值、以及糖化血红蛋白含量均低于对照组，P<0.05。实验组胰岛素功能指数高于对照组，胰岛B细胞功能恢复更优，P<0.05结果具有差异性。实验组血糖波动指标较对照组差异有统计学意义，P<0.05。实验组血糖达标天数短于对照组，数据比较差异具有统计学意义，P<0.05。结论 西格列汀和伏格列波糖联合实时动态胰岛素泵对于初发T2DM患者均有良好的治疗效果，西格列汀联合实时动态胰岛素泵对血糖的调节和胰岛细胞功能的提高效果更为显著。

[关键词] 西格列汀；伏格列波糖；实时动态胰岛素泵；初发T2DM

[中图分类号] R587.1 [文献标识码] A [文章编号] 2095-0616（2017）16-26-04

Effect of real-time dynamic insulin pump combined with different drugs in the treatment of patients with primary T2DM

LI Long1 WU Xiaomeng1 YUAN Xiumei2 WEI Wei1

1.Department of Pharmacy， the Second Affiliated Hospital of Mudanjiang Medical University， Mudanjiang 157000， China； 2.Department of Neurology， Hongqi Hospital Affiliated to Mudanjiang Medical University， Mudanjiang 157000， China

[Abstract] Objective To explore the clinical effect of Sig Leo Dean and the treatment of T2DM patients with the real-time dynamic insulin pump. Methods 104 patients with newly diagnosed type 2 diabetes from January 2013 to December 2015 in our hospital were chosen as the research object. According to the random number table method， the patients were divided into two groups， 52 cases in each group. All the patients were treated with basic treatment of diabetes， patiens in control group on the basis were treated withvoglibose combined with the real-time dynamic insulin pump treatment， and patients in observation group were treated with sitagliptin combined with the real-time dynamic insulin pump treatment. After 4 weeks of treatment， multinomial index of the two groups were compared. Results The blood glucose levels of the experimental group were significantly different from those of the control group. The level of blood glucose， fasting blood glucose， postprandial 2H blood glucose and glycosylated hemoglobin in the experimental group were lower than those in the control group， P<0.05. The insulin function index of the experimental group was higher than that of the control group， and the islet B cell function recovered better， P<0.05， and results were different. The blood glucose fluctuation index of the experimental group was significantly different from that of the control group， P<0.05. Conclusion Sig Leo Dean and glibenclamide combined with real-time dynamic insulin pump are effective for the treatment of newly diagnosed T2DM patients. The combination of gliclazide and real-time dynamic insulin pump has more remarkable effect on regulating blood glucose and improving the function of pancreatic islet cells.endprint

[Key words] Sig Leo Dean； Fu Bo wave sugar； Real time dynamic insulin pump； Primary T2DM

糖尿病（diabetes mellitus，DM）是对人类健康有着严重影响的慢性非传染疾病，随着经济水平的

不斷发展和人口老龄化不断加剧，其患病率在世界范围内呈现逐渐上升趋势[1-2]。目前我国糖尿病患者数量已达全球第一 [3]。糖尿病按照胰岛素分泌不

足和胰岛素对抗基本分为1型糖尿病和2型糖尿病（T2DM），2型糖尿病的发病率随着糖尿病发病率的上升也在不断提高，传统T2DM的治疗多采用药物治疗，以降糖药和胰岛素类药物为主，研究报道药物治疗能够获得一定的效果[4-5]。现探究实时动态胰岛素泵联合不同药物对T2DM的治疗效果，为2型糖尿病的治疗提供新的方向和依据。……