张文静

[摘要]目的研究奧氮平+碳酸锂治疗双相情感障碍躁狂发作的效果和用药安全性。方法选取2019年2月至2021年2月内蒙古自治区第三医院收治的100例双相情感障碍躁狂发作患者作为研究对象，根据随机分组原则分为观察组与对照组，每组各50例。观察组采用奥氮平+碳酸锂治疗，对照组采用常规治疗。比较两组蒙哥马利抑郁评定量表（MADRS）、杨氏躁狂评定量表（YMRS）、治疗效果、不良反应发生率。结果治疗前，两组 MARDS 评分比较，差异无统计学意义（P >0.05）;治疗后观察组 MARDS 评分为（0.19±0.01）分，低于对照组的（0.97±0.09）分、差异有统计学意义（ P <0.05）;观察组治疗总有效率高于对照组，差异有统计学意义（ P <0.05）;观察组治疗后 YMRS 评分低于对照组 YMRS 评分，差异有统计学意义（ P <0.05）。观察组不良反应发生率低于对照组，差异有统计学意义（ P <0.05）。结论奥氮平+碳酸锂治疗双相情感障碍躁狂发作的效果十分显著，并且安全性较高，能够显著改善狂躁症状。

[关键词]奥氮平;碳酸锂;双相情感障碍躁狂发作;用药安全性

[中图分类号] R473.74  [文献标识码] A   [文章编号]2095-0616（2021）23-0231-03

Efficacy and safety evaluation of olanzapine combined with lithium carbonate in the treatment ofbipolar affective disorder with manic episode

ZHANG  Wenjing

Emergency Ward， the Third Hospital of Inner Mongolia Autonomous Region， Inner Mongolia Autonomous Region， Hohhot 010010， China

[Abstract] Objective To study the efficacy and safety of olanzapine combined with lithium carbonate in the treatment of bipolar affective disorder （BAD） with manic episode. Methods A total of 100 patients with BAD with manic episode admitted to the third Hospital of Inner Mongolia Autonomous Region from February 2019 to February 2021 were selected as the research objects， and were randomly divided into the observation group and the control group， with 50 cases in each group. The observation group was treated with olanzapine combined with lithium carbonate， while the control group was treated with conventional treatment. The Montgomery-Asberg Depression Rating Scale （MADRS）， Young Mania Rating Scale （YMRS）， efficacy and incidence of adverse reactions were compared between the two groups. Results Before treatment， there was no significant difference in MADRS score between the two groups （P >0.05）. After treatment， the MADRS score of the observation group （0.19±0.01） was lower than that of the control group （0.97±0.09）， with statistically significant difference （P <0.05）. The total effective rate of treatment of the observation group was higher than that of the control group， with statistically significant difference （P <0.05）. The YMRS score of the observation group was lower than that of the control group after treatment， with statistically significant difference （P <0.05）. The incidence of adverse reactions in the observation group was lower than that in the control group， with statistically significant difference （P <0.05）. Conclusion Olanzapine combined with lithium carbonate is effective and safe in treating BAD with manic episode， which can significantly improve manic symptoms.

[Key words] Olanzapine; Lithium carbonate; Bipolar affective disorder with manic episode; Medication safety

双相情感障碍是一种抑郁以及躁狂交替发作的慢性精神性疾病，以情绪低落、情感高涨、精力充沛作为主要表现，多数患者伴有不规则发作、交替发作、反复发作等情况，为心境障碍[1]。临床对于该疾病的发生机制尚未明确，研究认为与环境因素、生物因素、遗传危险因素等相互作用具有密切关联性，进而引起神经发育性障碍、大脑功能失调。由于受到医疗技术条件的限制，导致无法识别和监测狂躁症的发作情况，而在疾病发作后给予有效的抗病药物治疗为关键。因此，本研究对奥氮平+碳酸锂治疗双相情感障碍躁狂发作的效果和用药安全性进行分析，现报道如下。

1资料与方法

1.1一般资料

選取2019年2月至2021年2月内蒙古自治区第三医院收治的100例双相情感障碍躁狂发作患者作为研究对象，根据随机分组原则分为观察组与对照组，每组各50例。纳入……