刘少玲 谢梅娟 谭雪群 严冰凤 徐国良

【摘 要】 目的：基于网络药理学方法研究益胃汤治疗慢性萎缩性胃炎的作用机制。方法：使用中药系统药理学数据库 （TCMSP）获取益胃汤药物活性成分，通过Swiss Target Prediction平台预测药物活性成分的潜在靶点，并检索OMIM、Gene Cards两大疾病靶点数据库，然后获得益胃汤治疗慢性萎缩性胃炎的作用靶点。使用String数据库和Cytoscape3.2.1软件构建PPI网络，选出degree值排名前10的作用靶点。通过Metascape平台对益胃汤治疗慢性萎缩性胃炎的作用靶点进行KEGG通路分析。结果：从益胃汤中得到13个药物活性成分，62个与益胃汤治疗慢性萎缩性胃炎相关的作用靶点。KEGG通路富集分析结果显示益胃汤治疗慢性萎缩性胃炎作用机制涉及PI3K-Akt信号通路、ERBB信号通路、EGFR酪氨酸激酶抑制剂耐药，雌激素信号通路等信号通路。结论：益胃汤通过“多成分-多靶点-多通路”模式对慢性萎缩性胃炎发挥着治疗作用。

【关键词】 益胃汤;网络药理学;慢性萎缩性胃炎;作用机制

【中图分类号】R285.5 【文献标志码】 A 【文章编号】1007-8517（2021）15-0043-06

Abstract：Objective To study the mechanism of YiWei Soup in the treatment of chronic atrophic gastritis based on network pharmacology.Methods The YiWei Soup active component was obtained by the Chinese Medicine System Pharmacology Database （TCMSP）， the potential target of the active ingredient was predicted by the Swiss Target Prediction platform，and the two major disease target databases of OMIM and Gene Cards was searched to obtain the target of YiWei Soup in treating chronic atrophic gastritis.The PPI network was built with the help of the String database and Cytoscape3.2.1software，and the top 10 targets of the degree value were screened.KEGG pathway analysis was performed on the target of Yiwei Soup in the treatment of chronic atrophic gastritis through the Metascape platform.Results 13 active ingredients of medicine were obtained from Yiwei Soup，and 62 targets related to the treatment of chronic atrophic gastritis by Yiwei Soup.KEGG pathway enrichment analysis results show that the mechanism of Yiwei Soup in the treatment of chronic atrophic gastritis involves PI3K-Akt signaling pathway，ERBB signaling pathway，EGFR tyrosine kinase inhibitor resistance，estrogen signaling pathway and other signaling pathways. Conclusions Yiwei Soup has a therapeutic effect on chronic atrophic gastritis through the “multi-component-multi-target-multi-pathway” model.

Keywords：YiWei Soup; Network Pharmacology; Chronic Atrophic Gastritis;Mechanism

慢性萎縮性胃炎（Chronic atrophic gastritis，CAG）是以胃黏膜上皮和腺体萎缩，数目减少，胃黏膜变薄，黏膜基层增厚，或伴幽门腺化生和肠腺化生，或有不典型增生为特征的慢性消化系统疾病，是一种多致病因素性疾病及癌前病变。目前认为该疾病的发生发展与幽门螺旋杆菌感染、胃肠动力下降，胆汁返流等因素密切相关[1]。世界卫生组织将CAG定义为胃癌前病变，其一般演变模式为“正常粘膜→慢性胃炎→CAG肠化生→不典型增生→胃癌”，因此及时地治疗CAG是防止胃癌发生的重要策略[2]。……