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[摘要] 目的 探讨坦洛新联合锯叶棕果实提取物软胶囊治疗良性前列腺增生的临床效果。 方法 将92例良性前列腺增生伴下尿路症状患者随机分为治疗组和对照组，各组46例，治疗组给予坦洛新缓释胶囊0.2 mg每晚饭后服，锯叶棕果实提取物软胶囊160 mg 2次/d饭后服；对照组给予坦洛新缓释胶囊0.2 mg每晚饭后服；疗程为3个月。治疗前后测量血压，查心电图、血尿常规、肝肾功能、血前列腺特异抗原（PSA）、前列腺彩超、国际前列腺症状评分（IPSS）、最大尿流率（Qmax）、夜尿次数、剩余尿量（RU）等，分析治疗前后各指标的变化及不良反应。 结果 治疗后两组患者的IPSS、QOL、Qmax、RU、夜尿次数改善明显，与治疗前比较差异有统计学意义（P<0.01，P<0.05），前列腺体积变化不大，差异无统计学意义（P>0.05）。治疗后两组患者的IPSS、QOL、Qmax、RU比较，差异有统计学意义（P<0.05）。未出现明显不良反应。 结论 坦洛新联合锯叶棕果实提取物治疗良性前列腺增生伴下尿路症状安全有效。

[关键词] 坦洛新；锯叶棕果实提取物；良性前列腺增生；下尿路症状

[中图分类号] R697+.32[文献标识码] A[文章编号] 1674-4721（2014）06（c）-0066-03

Clinical effect observation of tamsulosin combined with sabal fruit extract in soft capsule in the treatment of benign prostatic hyperplasia

ZHOU Xiao-pi YANG Ying-guo XU He-ping WAN Wen-yuan LIU Hui LIU Jun-ming ZHANG Ming-liangXIONG Guo-gen HUANG Zhi-qian

Department of Urinary Surgery,Affiliated Hospital of Nanchang Institute of Medical Sciences,Nanchang 330001,China

[Abstract] Objective To explore the effect of tamsulosin combined with sabal fruit extract in soft capsule in the treatment of benign prostatic hyperplasia (BPH). Methods Ninety-two cases of patients with BPH and lower urinary tract symptoms were evenly divided into treatment group and control group in random.In the treatment group,patients were treated by 0.2 mg tamsulosin spansule (after a meal,in the evening) and 160 mg Shabate (sabal fruit extract) (after a meal,twice per day),while in the control group,patients were only provided with 0.2 mg tamsulosin spansule (after a meal,in the evening).The course of treatment lasted 3 months.The blood pressure,electrocardiogram,blood/urine routine examinations,hepatorenal function,prostate specific antigen (PSA) in blood,color Doppler ultrasound of prostate,international prostate symptom score (IPSS),qave maximum (Qmax),frequency of nocturnal enuresis,and residual urine (RU) before and after treatment were measured or examined or calculated.The changes of above-mentioned indexes and adverse reaction before and after treatment were analyzed. Results The indexes of IPSS,QOL,Qmax,RU and frequency of nocturnal enuresis improved greatly after treatment compared with those before treatment in both groups,which displayed statistical differences (P<0.01,P<0.05);there was no obvious change in prostate volume,which didn′t display statistical difference in the two groups (P>0.05).After treatment,the indexes of IPSS,QOL,Qmax,and RU displayed statistical differences between two groups (P<0.05).There was no adverse reaction in both groups. Conclusion Combination of tamsulosin and sabal fruit extract is safe and effective on treating BPH with lower urinary tract symptoms.

[Key words] Tamsulosin;Sabal fruit extract;Benign prostatic hyperplasia;Lower urinary tract symptoms

良性前列腺增生（benign prostatic hyperplasia，BPH）是引起中老年男性排尿障碍原因中最常见的一种疾病，主要临床表现为下尿路症状（lower urinary tract symptoms，LUTS）。BPH通常发生在50岁以后，发病率随着年龄的增长而增加，严重影响中老年患者的身心健康和生活质量。目前治疗药物主要是5-α还原酶抑制剂和α-受体阻滞剂，由于疗效不稳定及长期用药的不良反应，植物类药物的临床应用倍受关注。本研究观察分析坦洛新联合锯叶棕果实提取物软胶囊治疗BPH的临床效果。

1 资料与方法

1.1 一般资料

选择2012年6月～2013年12月在本院门诊就诊的BPH伴有LUTS患者92例，年龄55～75岁，病程6个月～10年。……