邱华 李旺 舒发明 蒙荫杰 毛德文

【摘 要】 目的：觀察白花香莲解毒颗粒联合恩替卡韦分散片治疗乙型肝炎肝硬化代偿期的疗效。方法：选取乙型肝炎肝硬化代偿期患者60例，随机分为治疗组和对照组各30例，对照组给予恩替卡韦分散片治疗;治疗组给予白花香莲解毒颗粒联合恩替卡韦分散片治疗，两组均治疗48周。观察治疗后两组肝功能、HBV-DNA、肝纤四项水平及肝硬度值（LSM）的变化。结果：治疗后，两组血清HA、LN、IV-C、PC-Ⅲ水平与本组治疗前比较，差异均有统计学意义（P<0.05）;治疗后，治疗组血清HA、LN、IV-C、PC-Ⅲ水平低于同期对照组，差异均有统计学意义（P<0.05）;治疗后，治疗组在抑制HBV-DNA复制方面显著优于对照组（P<0.05）;治疗后，两组的TBIL、AST、ALT水平均低于治疗前，且治疗组均优于对照组，差异均具有统计学意义（P<0.05）。结论：白花香莲解毒颗粒可以有效改善乙型肝炎肝硬化代偿期患者肝纤维化，抑制病毒复制，改善肝功能指标。

【关键词】 白花香莲解毒颗粒;恩替卡韦分散片;慢性乙型肝炎;肝硬化代偿期;临床疗效

【中图分类号】R512.6+2   【文献标志码】 A    【文章编号】1007-8517（2021）19-0106-03

To Observe the Curative Effect of Baihua Xianglian Detoxification Granule in the Treatment of Hepatitis B Liver Cirrhosis in the Compensatory Phase

QIU Hua1 LI Wang2 SHU Faming1* MENG Yinjie2 MAO Dewen1

1.Department of Hepatology， the First Affiliated Hospital of Guangxi University of traditional Chinese Medicine，Nannning 530023， China;2.Graduate School of Guangxi University of traditional Chinese Medicine， Nanning 530001， China

Abstract：Objective To evaluate the efficacy of Baihua Xianglian Detoxification Granule combined with Entecavir Dispersible Tablets in the treatment of hepatitis B liver cirrhosis in the compensatory phase.Methods 60 patients with compensated hepatitis B cirrhosis were selected and randomly divided into treatment group and control group， 30 cases in each group. The treatment group was given Baihualian Jiedu Granules combined with Entecavir dispersible tablets， while the control group was given Entecavir dispersible tablets. Both groups were treated for 48 weeks.The changes of liver function， HBV-DNA， liver fiber and liver hardness （LSM） in 2 groups were observed after treatment.Results after treatment， two groups of patients serum HA， LN， IV-C， PC-Ⅲ levels compared with before this treatment， difference have statistical significance（P<0.05）;After treatment， the treatment group of serum HA， LN， IV-C， PC-Ⅲ level lower than control group during this period， the difference had statistical significance（P<0.05）;After treatment， the inhibition of HBV-DNA replication in the treatment group was significantly better than that in the control group（P<0.05）;After treatment， the levels of TBIL， AST and ALT in 2 groups were lower than before treatment， and the treatment group was better than the control group， with statistical significance（P<0.05）.Conclusion Baihualianjiedu granule can effectively improve liver fibrosis， inhibit virus replication and improve liver function index in patients with hepatitis B cirrhosis.

Key words：Baihua Xianglian Detoxification Granule; Entecavir Dispersible Tablets; Chronic Hepatitis B; Compensatory Period of Liver Cirrhosis;Clinical Curative Effect

肝硬化作为一种全球性常见疾病，常常是多种慢性肝脏疾病的共同结局，被视为人类健康的主要“杀手”之一，其发病率呈逐年上升趋势[1]。乙肝肝硬化患者若不能得到及时治疗，一旦进入失代偿期，可能会发生消化道出血、肝性脑病、肝肾综合征等严重并发症，甚至可发展为肝癌，严重危害患者的生命安全[2]。因此，对该病患者进行早期确诊，并进行积极治疗对控制和逆转肝硬化患者的病情至关重要。本研究选择本院60例乙肝肝硬化代偿期患者作为研究对象，观察治疗前后HBV-DNA、肝功能、肝纤四项、肝硬度值的变化，评价白花香莲解毒颗粒联合恩替卡韦分散片治疗乙肝肝硬化代偿期的临床疗效，现报道如下。

1 资料与方法

1.1 一般资料 选取2018年10月至2019年10月就诊于广西中医药大学第一附属医院门诊及住院60例患者为研究对象，随机分为治疗组和对照组，每组各30例。……