纪玉红 司晓盼

[摘要] 目的 探討血清C反应蛋白（CRP）及降钙素原（PCT）在成人急性细菌性肺炎早期诊断中的应用价值。 方法 选择2018年5月至2019年5月期间在我院接受治疗的80例成人急性细菌性肺炎及同期在我院接受健康体检的80例健康成人作为临床研究对象，所有参与研究的人员均进行血清CRP及PCT检测。以健康体检者的检测结果为对照组，以患者的检测结果为观察组。观察组中又以刚入院时该疾病患者的检测结果为观察1组，以接受1周治疗后该疾病患者的检测结果为观察2组，比较三组的检查结果。 结果 观察1组、观察2组患者的CRP、PCT水平显著高于对照组，差异有统计学意义（P<0.05）;观察1组患者的CRP、PCT水平显著高于观察2组，差异有统计学意义（P<0.05）;对照组血清CRP、PCT水平检测以及联合检测阳性率均为0.00%，观察组患者的联合检测阳性率（97.50%）显著高于CRP单独检测阳性率（85.00%）及PCT单独检测阳性率（82.50%），差异有统计学意义（P<0.05）。 结论 在成人急性细菌性肺炎早期诊断中，CRP及PCT两项指标具有较高的辅助诊断价值，且联合诊断的准确率显著高于分别单独诊断。

[关键词] 血清C反应蛋白;降钙素原;成人急性细菌性肺炎;早期诊断;应用价值

[中图分类号] R446.6          [文献标识码] B          [文章编号] 1673-9701（2021）06-0137-04

The application value of serum C-reactive protein and procalcitonin in early diagnosis of adult acute bacterial pneumonia

JI Yuhong   SI Xiaopan

Department of Clinical Laboratory，the Second Hospital of Chaoyang City in Liaoning Province，Chaoyang   122000，China

[Abstract] Objective To investigate the application value of serum C-reactive protein（CRP） and procalcitonin （PCT） in early diagnosis of adult acute bacterial pneumonia. Methods A total of 80 cases of adult acute bacterial pneumonia admitted to our hospital from May 2018 to May 2019 and 80 healthy adults who were given physical examination in our hospital at the same time were selected as the clinical research objects，and all participants in the research were examined for CRP and PCT. The results of physical examination were taken as the control group，while the results of patients were taken as the observation group. In the observation group，the examination results of patients with the disease at the time of admission were taken as the observation group 1，and the examination results of patients with the disease after 1 week of treatment were taken as the observation group 2. Meanwhile，the examination results among the three groups were compared. Results After examination，the levels of CRP and PCT in the observation group 1 and observation group 2 were significantly higher than those in the control group，with statistically significant differences（P<0.05）. The levels of CRP and PCT in the observation group 1 were significantly higher than those in the observation group 2，with statistically significant differences（P<0.05）. The positive rates of serum CRP，PCT and combined examination were all 0.00% in the control group，while the positive rates of combined examination（97.50%） in the observation group were significantly higher than those of CRP（85.00%） and PCT（82.50%） separately，with statistically significant differences （P<0.05）. Conclusion In the early diagnosis of adult acute bacterial pneumonia，CRP and PCT indexes have high auxiliary diagnostic values，and the accuracy of combined diagnosis is significantly higher than that of respectively separate diagnosis.

[Key words] Serum C-reactive protein; Procalcitonin; Adult acute bacterial pneumonia; Early diagnosis; Application value

肺炎属于临床高发疾病，是指终末气道、肺间质以及肺泡之间有炎症反应出现，不同年龄段均可患病，多为细菌、病毒以及寄生虫诱发，主要致病微生物为细菌[1]。受喜食生物、环境污染等多种因素影响，近年来该疾病在我国的患病率呈逐年递增趋势，导致患者的身心健康受到了严重影响[2-3]。且急性细菌性肺炎病情进展较为迅速，初期临床表现为发热、咳嗽，并伴有呼吸困难、胸痛，如未及时给予抗感染治疗，极易出现感染性休克的风险，对患者的生命安全造成威胁[4]。故该疾病的早期诊断尤为重要，而目前临床对该疾病的诊断方式较多，C反应蛋白（C-reactive protein，CRP）及降钙素原（Procalcitonin，PCT）就为其中常见的……