综合用药对肺炎支原体感染患儿免疫、血清及睡眠质量的影响
2020-10-21殷世超
殷世超


摘要 目的:探討普米克令舒联用阿奇霉素、孟鲁司特钠对肺炎支原体感染患儿免疫功能、血清因子及睡眠质量的影响。方法:选取2017年11月至2018年11月蚌埠市第三人民医院儿科收治的肺炎支原体感染患儿96例作为研究对象,随机分为对照组与观察组,每组48例。对照组患儿采用阿奇霉素、孟鲁司特钠进行治疗,观察组患儿在对照组的基础上联用普米克令舒治疗,统计整合2组治疗的相关数据指标情况并进行比较。结果:观察组临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);观察组治疗后炎性因子水平明显优于对照组,差异有统计学意义(P<0.05);观察组治疗后免疫功能水平明显优于对照组,差异有统计学意义(P<0.05);观察组治疗后睡眠质量评分明显高于对照组,差异有统计学意义(P<0.05)。结论:小儿肺炎支原体感染的治疗中,采用普米克令舒联用阿奇霉素、孟鲁司特钠可有效缩短临床症状消失时间,患儿免疫功能等指标得到改善,有较高的临床价值。
关键词 普米克令舒;阿奇霉素;肺炎支原体感染;免疫功能;血清因子;睡眠质量
Effects of Comprehensive Drug Administration on Immunity Serum and Sleep Quality of Children with Mycoplasma Pneumoniae Infection
YIN Shichao
(Bengbu third people′s hospital,Bengbu 233000,China)
Abstract Objective:To investigate the effects of pulmicrine combined with azithromycin and montelukast sodium on immune function,serum factors and sleep quality in children with mycoplasma pneumoniae infection.Methods:A total of 96 children with mycoplasma pneumoniae infection admitted to the department of pediatrics of bengbu third people′s hospital from November 2017 to November 2018 were randomly divided into control group and observation group,with 48 cases in each group.The children in the control group were treated with azithromycin and montelukast sodium.The children in the observation group were treated with pulmicrine on the basis of the control group.The data indicators of the two groups were statistically integrated and compared.Results:The disappearance time of clinical symptoms in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The levels of inflammatory factors in the observation group were significantly better than those in the control group,with statistically significant differences(P<0.05).After treatment,the level of immune function of the observation group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).The score of sleep quality in the observation group was significantly higher than that in the control group(P<0.05).Conclusion:In the treatment of mycoplasma pneumoniae infection in children,the use of pulmicorrine combined with azithromycin and montelukast sodium can effectively shorten the time of the disappearance of clinical symptoms and improve the immune function of children.
3 讨论
肺炎支原体感染是一种下呼吸道疾病,是临床上儿科常见的一种肺部疾病。近几年肺炎支原体感染发病率呈攀升趋势,肺炎支原体感染发病人群多在3岁以下的小儿,因肺炎支原体感染疾病威胁着患儿的生命安全,所以在临床治疗中一直寻找合适于小儿的治疗方法,使治疗不良反应最小化。有相关研究表明[7],肺炎支原体感染的发病机制可能与病原体直接侵袭肺组织有关。但在王志平[8]等人的研究中,病原菌感染后,机体免疫功能受到干扰,系统和组织受到破坏。炎性反应和免疫功能障碍可进一步加重该病的发展,这是支原体肺炎儿童死亡的高危因素。所以肺炎支原体感染,应及早介入治疗,为患儿选择合适的治疗方法可缩短患儿病程,从而提高肺炎支原体感染的治愈率。……
