黄绮筠 许柏华 钟小敏

【摘要】 目的：研究呼吸道核酸联合降钙素原（PCT）对细菌性肺炎患儿的诊断价值。方法：选取2018年5月-2019年10月于筆者所在医院儿科接受治疗的细菌性肺炎患儿90例作为研究对象。按照诊断方法分为核酸组、PCT组及联合组，每组30例，分别接受呼吸道核酸检测、PCT检测及呼吸道核酸联合PCT检测。对比三组确诊率。结果：核酸组中，核酸检测结果为阳性19例，确诊率为63.33%;PCT组中，确诊为细菌性肺炎17例，确诊率为56.67%;联合组中，确诊为细菌性肺炎29例，确诊率为96.67%。核酸组与PCT组确诊率比较，差异无统计学意义（P>0.05）;联合组确诊率显著高于核酸组和PCT组，差异有统计学意义（P<0.05）。结论：在细菌性肺炎患儿的临床诊断中，呼吸道核酸联合PCT检测的确诊率最高，具有较高的诊断价值。

【关键词】 细菌性肺炎 核酸检测 降钙素原 联合诊断

doi：10.14033/j.cnki.cfmr.2020.19.035 文献标识码 B 文章编号 1674-6805（2020）19-00-02

Diagnostic Value of Respiratory Nucleic Acid Combined with Procalcitonin in Children with Bacterial Pneumonia/HUANG Qiyun， XU Bohua， ZHONG Xiaomin. //Chinese and Foreign Medical Research， 2020， 18（19）： -88

[Abstract] Objective： To investigate the diagnostic value of respiratory nucleic acid combined with procalcitonin （PCT） in children with bacterial pneumonia. Method： From May 2018 to October 2019， 90 children with bacterial pneumonia treated in the pediatric department of our hospital were selected as the research objects. According to the diagnostic methods， the children were divided into the nucleic acid group， the PCT group and the combined group， with 30 children in each group， and the detections of respiratory nucleic acid， PCT and respiratory nucleic acid combined with PCT were performed respectively. The diagnosis rate of the three groups was compared. Result： In the nucleic acid group， the results of nucleic acid detection in 19 children were positive， the diagnosis rate was 63.33%. In the PCT group， 17 children were diagnosed as bacterial pneumonia， the diagnosis rate was 56.67%. In the combined group， 29 children were diagnosed as bacterial pneumonia， the diagnosis rate was 96.67%. The diagnosis rate of the nucleic acid group and the PCT group was compared， and the difference was not statistically significant （P>0.05）. The diagnosis rate of the combined group was significantly higher than that of the nucleic acid group and the PCT group， and the difference was statistically significant （P<0.05）. Conclusion： In the clinical diagnosis of bacterial pneumonia children， respiratory nucleic acid combined with PCT detection has the highest diagnosis rate， which has a high diagnostic value.

[Key words] Bacterial pneumonia Nucleic acid detection Procalcitonin Combined diagnosis

First-authors address： Tung Wah Hospital Affiliated to Sun Yat-sen University， Dongguan 523000， China

细菌性肺炎是儿童呼吸系统常见多发疾病，是由细菌感染所致的肺部炎症，在小儿感染类疾病中的发病率较高[1]。细菌性肺炎会导致患儿出现发热、咳嗽等症状，肺部可闻及干湿性啰音，严重者可并发重症肺炎、呼吸衰竭而危及生命。因此，对于疑似患病的儿童必须尽早确诊并采取积极有效的治疗措施，降低病毒性心肌炎、重症肺炎、感染性休克等并发症发生率[2]。由于细菌性肺炎与小儿哮喘等呼吸系统疾病的临床表现相似，因此以患儿临床表现作为诊断依据不可靠[3]。常见肺炎病原体有病毒、细菌、支原体等。研究显示，呼吸道核酸联合PCT对细菌性肺炎有较好的诊断价值[1]。本文围绕呼吸道核酸联合PCT检测对细菌性肺炎患儿的诊断价值展开研究，报道如下。