赵涛 杨剑波 邵继春

【摘要】 目的：探究循環血miR指标与前列腺癌分期及分化程度的关系。方法：选取2017年1月-2018年12月的75例前列腺癌患者为观察组，另选取同时期的75例健康者设为对照组。比较两组循环血miR指标（miR-152、miR-141及miR-27a），同时比较观察组不同分期及分化程度患者循环血miR指标。采用Spearman等级相关性分析循环血miR指标与前列腺癌分期及分化程度的关系。结果：观察组循环血miR-152低于对照组，循环血miR-141及miR-27a高于对照组，差异均有统计学意义（P<0.05）。观察组不同分期及分化程度患者循环血miR-152、miR-141及miR-27a比较，差异均有统计学意义（P<0.05）。Spearman等级相关性分析显示，miR-152与前列腺癌分期呈负相关，与分化程度呈正相关，miR-141及miR-27a与前列腺癌分期呈正相关，与分化程度呈负相关（P<0.05）。结论：前列腺癌患者的循环血miR指标异常表达，且与分期及分化程度有密切的关系，可作为前列腺癌诊治的参考依据。

【关键词】 循环血miR指标 前列腺癌 分期 分化程度

doi：10.14033/j.cnki.cfmr.2020.19.025 文献标识码 B 文章编号 1674-6805（2020）19-00-02

Investigation on the Relationship Between Circulating Blood miR Indexes and Prostate Cancer Stage and Differentiation Degree/ZHAO Tao， YANG Jianbo， SHAO Jichun. //Chinese and Foreign Medical Research， 2020， 18（19）： -65

[Abstract] Objective： To investigate the relationship between circulating blood miR indexes and prostate cancer stage and differentiation degree. Method： Seventy-five patients with prostate cancer from January 2017 to December 2018 were selected as the observation group， and 75 healthy persons in the same period were selected as the control group. The circulating blood miR indexes （miR-152， miR-141 and miR-27a） of the two groups were compared，and the circulating blood miR indexes of patients with different stages and differentiation degree of the observation group were compared. The relationship between circulating blood miR indexes and prostate cancer stage and differentiation degree were analyzed by Spearman rank correlation. Result： The circulating blood miR-152 of the observation group was lower than that of control group，the circulating blood miR-141 and miR-27a were higher than those of the control group， the differences were statistically significant （P<0.05）. There were statistically significant differences in miR-152， miR-141 and miR-27a among patients with different stages and differentiation degree in the observation group（P<0.05）. Spearman rank correlation analysis showed that miR-152 was negatively correlated with prostate cancer stage and positively correlated with differentiation degree， while miR-141 and miR-27a were positively correlated with the prostate cancer stage and negatively correlated with differentiation degree （P<0.05）. Conclusion： The abnormal expression of circulating blood miR indexes in prostate cancer patients is closely related to the stage and differentiation degree， which can be used as a reference for diagnosis and treatment of prostate cancer.

[Key words] Circulating blood miR indexes Prostate cancer Stage Differentiation degree

First-authors address： The Second Affiliated Hospital of Chengdu Medical College， Nuclear Industy 416 Hospital， Chengdu 610000， China

前列腺癌是男性中并不少见的一类恶性肿瘤，本类患者的研究方面中，miR是研究较热的一个方面，关于其在前列腺癌患者中的表达变化及对疾病的诊断作用，研究显示，较多相关指标在本类患者中呈现显著异常的状态，但是对于其在前列腺癌分期及分化程度中的细致检测价值仍有待进一步研究[1-2]。本研究就循环血miR指标与前列腺癌分期及分化程度的关系进行探究，现将结果报道如下。

1 资料与方法

1.1 一般资料

选取2017年1月-2018年12月的75例前列腺癌患者设为观察组，纳入标准：20岁以上者。排除标准：合并感染者;合并其他前列腺疾病者;合并慢性基础疾病者;进行相关治疗者。另选取同时期的75例健康者设为对照组。对照组年龄40～79岁，平均（70.5±6.0）岁。观察组年龄39～79岁，平均（70.3±6.2）岁;

分期：Ⅰ期12例，Ⅱ期20例，Ⅲ期25例，Ⅳ期18例;分化程度：高分化35例，中分化23例，低分化17例。两组年龄比较差异无统计学意义（P>0.05），有可比性。本研究已经医院伦理委员会批准。研……