王新

[摘要] 目的 探究左氧氟沙星与莫西沙星治疗耐药性肺结核的疗效和安全性。方法 方便选取2014年1月—2016年1月期间，该院收治的60例耐药性肺结核患者作为研究对象，按照治疗分为对照组（n=30）和治疗组（n=30），对照组采用左氧氟沙星治疗，治疗组采用莫西沙星治疗，观察分析两组患者的治疗效果，不同时期痰菌转阴情况、X线空洞病变变化情况和不良反应发生率。 结果 治疗组患者的治疗总有效率93.33%远高于对照组患者的治疗总有效率73.33%，不良反应发生率（3.33%）低于对照组患者的不良反应发生率（26.67%），不同时期痰菌转阴情况、X线空洞病变变化情况好于对照组，两组患者的治疗效果，不同时期痰菌转阴情况、X线空洞病变变化情况和不良反应发生率差异有统计学意义（P<0.05）。结论 采用莫西沙星治疗耐药性肺结核具有较大的意义，可有效提高患者的治疗效果，值的临床信赖。

[关键词] 左氧氟沙星；莫西沙星；耐药性肺结核；临床疗效；安全性

[中图分类号] R521 [文献标识码] A [文章编号] 1674-0742（2017）02（c）-0141-03

Study on Curative Effect and Safety of Levofloxacin and Moxifloxacin in Treatment of Drug-resistant Pulmonary Tuberculosis

WANG Xin

Department of Infection， Chongqing Southwest Aluminum Hospital，Chongqing， 401326 China

[Abstract] Objective To study the curative effect and safety of Levofloxacin and moxifloxacin in treatment of drug-resistant pulmonary tuberculosis. Methods Convenient selection 60 cases of patients with drug-resistant pulmonary tuberculosis admitted and treated in our hospital from January 2014 to January 2016 were selected as the research objects and divided into two groups with 30 cases in each， the control group were treated with Levofloxacin， while the treatment group were treated with moxifloxacin， and the treatment effect， sputum smear conversion situations during different stages， X ray cavity disease change and incidence rate of adverse reactions of the two groups were observed and analyzed. Results The total treatment effective rate in the treatment group was much higher than that in the control group（93.33% vs 73.33%）， and the incidence rate of adverse reactions was lower than that in the control group（3.33% vs 26.67%）， and the differences in the sputum smear conversion situations during different stages， X ray cavity disease change and incidence rate of adverse reactions between the two groups had statistical significance（P<0.05）. Conclusion The moxifloxacin in treatment of drug-resistant pulmonary tuberculosis is of great significance， which can effectively improve the treatment effect of patients， and it is worth trust.

[Key words] Levofloxacin； Moxifloxacin； Drug-resistant pulmonary tuberculosis； Clinical curative effect； Safety

耐藥性肺结核是一种临床上较为常见的结核病，异烟肼、链霉素等药物的滥用是产生耐药性的重要原因。目前，我国的耐药性肺结核在临床的发病率越来越高，相关医务人员的重视程度也在增大[1]。该病自身具有一定的耐药性，治疗方案具有用药时间长、费用高以及治疗效果差等情况。常规药物治疗该病的效果较差，目前，临床上逐渐开始尝试采用左氧氟沙星和莫西沙星等抗结核药物治疗[2]。为此，方便选取2014年1月—2016年1月期间，该院收治的60例耐药性肺结核患者作为研究对象进行对照分析，现报道如下。……