彭燚焱 严小敏

摘 要 目的：探讨麝香保心丸联合阿托伐他汀治疗冠心病合并高血脂患者的疗效。方法：选取冠心病合并高血脂患者100例，按照随机数字表法，分为对照组和观察组各50例。对照组给予阿托伐他汀治疗，观察组给予阿托伐他汀联合麝香保心丸治疗，两组疗程均为3个月。结果：两组患者的心绞痛发作持续时间都缩短、发作的次数均减少；观察组的总有效率高于对照组，血脂水平指标优于对照组，内皮舒张功能改善优于对照组，LAD、IVSD低于对照组，LVEF水平高于对照组（P<0.05）。结论：麝香保心丸联合阿托伐他汀治疗冠心病合并高血脂，能进一步改善患者内皮舒张功能、心脏功能及血脂水平，提高临床疗效。

关键词 麝香保心丸 阿托伐他汀 冠心病 高血脂 临床疗效

中图分类号：R286； R541.4 文献标志码：A 文章编号：1006-1533（2021）17-0037-03

Efficacy of Shexiang Baoxin pills combined with atorvastatin in the treatment of coronary heart disease with hyperlipidemia

PENG Yiyan， YAN Xiaomin

（Department of Intensive Care Unit， the Peoples Hospital of Huichang County， Ganzhou 342600， China）

ABSTRACT Objective： To explore the effects of Shexiang Baoxin pill combined with atorvastatin in the treatment of patients with coronary heart disease complicated with hyperlipidemia. Methods： One hundred cases of the patients were selected and divided into a control group and an observation group with 50 cases each based on the random indicator method. The control group was treated only with oral atorvastatin while the observation group with both atorvastatin and Shexiang Baoxin pill， and the treatment was lasted for 3 months. Results： The duration of angina pectoris episodes was shortened and the times of episodes decreased in both groups. The total effective rate and LVEF levels was higher， LAD， IVSD levels were lower， and the blood lipid levels and the improvement of endothelial diastolic function were much better in the observation group than the control group（P<0.05）. Conclusion： Shexiang Baoxin pill combined with atorvastatin for the treatment of coronary heart disease complicated with hyperlipidemia can further improve the heart and endothelium diastolic function， reduce blood lipid level and increase clinical efficacy.

KEy WORDS Shexiang Baoxin pill； atorvastatin； coronary heart disease； hyperlipidemia； clinical efficacy

随着社会经济的发展，人们的生活越来越富裕，心血管疾病发病的人数持续上升。目前，心血管疾病占据中国城乡居民总死亡原因的首位，其中农村为45.50%，城市为43.16%[1]。冠心病是常见的心血管疾病，其病理机制是冠状动脉粥样硬化引起血管管腔狭窄或阻塞，造成心肌缺血、缺氧坏死。主要表现为胸前区压榨性疼痛。血脂异常是导致冠心病的主要危险因素[2]。他汀类药物是临床上治疗冠心病合并高血脂的常见药，其主要的作用是降低血浆中脂蛋白和胆固醇的水平，减少低密度脂蛋白的产生[3]。中西药结合治疗能提高整体的疗效，研究表明，麝香保心丸的主要成分人参总皂甙、麝香、苏合香、冰片，有减缓心绞痛、心肌梗死和缺血的症状，改善心肌血流灌注，增加心肌耐氧力的作用[4-5]。

1 资料与方法