临床药师参与左心室辅助装置植入术后感染治疗的病例分析
2021-10-09李雪张寒娟于丽
李雪 张寒娟 于丽

摘 要 目的:为临床左心室辅助装置植入术后感染患者的治疗提供参考依据与用药经验。方法:临床药师参与1例左心室辅助装置植入术后感染的治疗,协助医师制定给药方案,密切关注药物相互作用,提出个体化用药建议,并对患者进行药学监护。结果:临床药师根据血药浓度监测结果及时调整给药方案,治疗效果显著。结论:临床药师运用专业的药学知识与思维,协助治疗过程,保证了疗效,减少了不良反应的发生,体现了临床药师在多学科诊疗中的积极作用。
关键词 左心室辅助装置 心力衰竭 伏立康唑
中图分类号:R619.3; R654.2 文献标志码:B 文章编号:1006-1533(2021)17-0067-03
Case analysis of clinical pharmacist participating in the treatment of infection after left ventricular assist device implantation
LI Xue, ZHANG Hanjuan, YU Li
(Department of Pharmacy, the Seventh Peoples Hospital of Zhengzhou, Zhengzhou 450016, China)
ABSTRACT Objective: To provide reference basis and medication experience for the treatment of patients with infection after left ventricular assist device implantation. Methods: A clinical pharmacist participated in the consultation treatment of a case of infection after the implantation of the left ventricular assist device, assisted physicians in formulating drug administration plan, proposed individualized medication recommendations, and provided pharmaceutical care for the patient. Results: The therapeutic effect was significant after the administration plan was adjusted in time by the clinical pharmacist according to the results of the monitoring of blood concentrations. Conclusion: Clinical pharmacists use their professional pharmaceutical knowledge and thinking to assist physicians in the treatment process, which can ensure the curative effect, reduce the occurrence of adverse reactions, reflect the positive role of clinical pharmacists in multidisciplinary diagnosis and treatment.
KEy WORDS left ventricular assist devices; heart failure; voriconazole
左心室輔助装置(left ventricular assist device, LVAD)可提高终末期心力衰竭患者的生存率并降低其发病率[1-2]。感染是LVAD植入术后常见的并发症[3]。在过去的几年中,美国LVAD的临床应用呈稳步增长状态,然而在我国,接受LVAD管理的患者人数相对较少,关于LVAD感染的发生率、临床表现和预后的信息有限,且对于其术后抗感染的治疗方法尚未达成共识。因此本文通过临床药师参与的1例左心室辅助装置植入术后感染的病例进行分析,为临床上这一特殊群体的抗感染治疗提供个体化的参考依据。
1 病例资料
患者,男,45岁,体质量78.9 kg。主因“胸憋、气短、四肢末梢凉1 d”入院。患者于6年前无明显诱因出现咳嗽、咳痰,伴呕吐,当地医院诊断为“扩张型心肌病”,期间多次住院治疗,纠正心衰后症状缓解。2021年3月17日以症状加重,胸闷难以缓解于郑州市第七人民医院就诊。……
