王腾腾 张鹭坚

【摘要】 目的：探討NT-proBNP在慢性心力衰竭患者中的水平变化及与心肌肌钙蛋白I（cTnI）的相关性。方法：选取笔者所在医院于2016年7月-2019年7月收诊的62例慢性心力衰竭患者作为观察组，另选取同期于笔者所在医院体检的62例健康体检者设为对照组。比较两组cTnI、NT-proBNP与LVEF水平，以及观察组不同心功能等级患者cTnI、NT-proBNP与LVEF水平。分析NT-proBNP与cTnI的相关性。结果：对照组cTnI、NT-proBNP与LVEF水平均优于研究组，差异有统计学意义（P<0.05）。观察组心功能Ⅳ级患者cTnI、NT-proBNP水平均高于心功能Ⅲ级及心功能Ⅱ级患者，且心功能Ⅲ级患者高于心功能Ⅱ级患者，差异均有统计学意义（P<0.05）。观察组心功能Ⅳ级患者LVEF水平低于心功能Ⅲ级及心功能Ⅱ级患者，且心功能Ⅲ级患者低于心功能Ⅱ级患者，差异均有统计学意义（P<0.05）。Pearson相关性分析显示，血清NT-proBNP与cTnI呈正相关，和LVEF为负相关（P<0.05）。结论：cTnI、NT-proBNP可对患者是否罹患慢性心力衰竭进行检测，同时可检测其心功能水平，值得推广。

【关键词】 心肌肌钙蛋白I 慢性心力衰竭 NT-proBNP 相关性

doi：10.14033/j.cnki.cfmr.2020.13.032 文献标识码 B 文章编号 1674-6805（2020）13-00-02

NT-proBNP Level Change in Patients with Chronic Heart Failure and Its Correlation with Cardiac Troponin I/WANG Tengteng， ZHANG Lujian. //Chinese and Foreign Medical Research， 2020， 18（13）： -80

[Abstract] Objective： To investigate the level change of NT-proBNP in patients with chronic heart failure and its correlation with cardiac troponin I （cTnI）. Method： A total of 62 patients with chronic heart failure who were admitted in our hospital from July 2016 to July 2019 were selected as the observation group， and 62 healthy patients who were examined at our hospital during the same period were selected as the control group. The cTnI， NT-proBNP and LVEF levels of the two groups were compared， and the cTnI， NT-proBNP and LVEF levels of patients with different cardiac function grade in the observation group were compared. The correlation between NT-proBNP and cTnI was analyzed. Result： The levels of cTnI， NT-proBNP and LVEF in the control group were better than those in the observation group， and the differences were statistically significant （P<0.05）. In the observation group， the level of cTnI and NT-proBNP in patients with cardiac function grade Ⅳ were higher than those in patients with cardiac function grade Ⅲ and Ⅱ， and those in patients with cardiac function grade Ⅲ were higher than those in patients with cardiac function grade Ⅱ， and the differences were statistically significant （P<0.05）. In the observation group， the level of LVEF in patients with cardiac function grade Ⅳ was lower than that in patients with cardiac function grade Ⅲ and Ⅱ， and that in patients with cardiac function grade Ⅲ was lower than that in patients with cardiac function grade Ⅱ， and the differences were statistically significant （P<0.05）. Pearson correlation analysis showed that serum NT-proBNP was positively correlated with cTnI and negatively correlated with LVEF （P<0.05）. Conclusion： cTnI and NT-proBNP can be used to detect whether the patient suffers from chronic heart failure， and at the same time to detect the level of cardiac function， which is worthy of promotion.

[Key words] Cardiac troponin I Chronic heart failure NT-proBNP Correlation

First-authors address： The First Affiliated Hospital of Xiamen University， Xiamen 361001， China

近年来心脏瓣膜病、冠心病及高血压等心血管疾病的罹患群体，随着民众日常生活习惯改变而得到明显扩张[1]，该类疾病恶化后常表现为慢性心力衰竭，易增加病死率[2]。各大医疗机构为对慢性心力衰竭进行疾病防治、控制，常通过cTnI、NT-proBNP对患者实施联合检测[3]。本研究特探讨了NT-proBNP在慢性心力衰竭患者中的水平变化及与心肌肌钙蛋白I（cTnI）的相关性，现报道如下。

1 资料与方法

1.1 一般资料

選取笔者所在医院于2016年7月-2019年7月收诊的62例慢性心力衰竭患者作为观察组，另选取同期于笔者所在医院体检的62例健康体检者设为对照组，纳入标准：临床相关资料无缺失，观察组患者病情均符合慢性心力衰竭标准[4]。排除标准：（1）心功能Ⅰ级者。（2）表达能力障碍。（3）原发性肺部疾病。（4）严重感染性疾病。观察组中女24例，男38例;年龄57～84岁，平均（69.02±7.26）岁;心功能分级：28例Ⅱ级，20例Ⅲ级，14例Ⅳ级。对照组中女26例，男36例;年龄58～86岁，平均（69.76±7.17）岁。两组性别、年龄比较，差异无统计学意义（P>0.05），有可比性。研……