马昭娟+袁建喜

【摘要】 目的：探讨阿托伐他汀联合中医中药改善慢性心力衰竭预后的效果。方法：将100例慢性心力衰竭心功能NY-HA分级Ⅱ～Ⅳ级的患者随机分为对照组48例与治疗组52例，对照组给予常规治疗，包括洋地黄、血管紧张素酶抑制剂、β受体抑制剂、利尿剂等；治疗组在对照组治疗的基础上，给予口服阿托伐他汀，同时口服中药。所有患者治疗8周后复查。结果：治疗后，治疗组总有效率78.8%，高于对照组的45.8%，差异有统计学意义（P<0.01），且治疗组死亡率显著低于对照组，差异有统计学意义（P<0.01）。治疗后，两组TC、LDL-C、CRP均低于治疗前，LVEF高于治疗前；治疗组TC、LDL-C、CRP均低于对照组，LVEF高于对照组，差异均有统计学意义（P<0.05）。两组住院次数、住院时间比较差异无统计学意义（P>0.05）。结论：应用阿托伐他汀联合中医中药治疗心力衰竭患者方法简便、疗效好，可显著提高患者的治疗效果，有临床推广应用价值。

【关键词】 阿托伐汀； 中医中药； 慢性心力衰竭； 心室重塑； 疗效； 预后

中图分类号 R541.6 文献标识码 A 文章编号 1674-6805（2016）24-0004-03

【Abstract】 Objective：To investigate the effect of Atorvastatin combined with traditional Chinese medicine in improving the prognosis of patients with chronic heart failure.Method：100 cases of chronic heart failure patients whose cardiac function NY-HA grade was Ⅱ-Ⅳ grade were randomly divided into the control group （48 cases） and treatment group （52 cases）.The control group was treated with conventional treatment，including Digitalis，angiotensin enzyme inhibitor，beta blockers and diuretics.The treatment group on the basis of the control group was given oral Atorvastatin and traditional Chinese medicine.After 8 weeks of treatment，all patients were reviewed.Result：After treatment，the total effective rate of the treatment group was 78.8%，higher than 45.8% of the control group，the difference was statistically significant（P<0.01），and the death rate of the treatment group was significantly lower than that of the control group，the difference was statistically significant（P<0.01）.After treatment，the TC，LDL-C and C-reactive protein of the two groups were lower than before treatment，and the left ventricular ejection fraction（LVEF） was higher than before treatment，the TC，LDL-C and C-reactive protein of the treatment group were lower than those of the control group，and the left ventricular ejection fraction（LVEF） was higher than that of the control group，the differences were statistically significant（P<0.05）.There was no statistically significant difference in the number of times of hospitalization and the total length of stay between the two groups（P>0.05）.Conclusion：The application of Atorvastatin combined with traditional Chinese medicine in the treatment of chronic heart failure is simple and effective，it can significantly improve the treatment effect，which has the value of clinical application.

【Key words】 Atorvastatin； Traditional Chinese medicine； Chronic heart failure； Ventricular remodeling； Curative effect； Prognosis

First-authors address：Traditional Chinese Medicine Hospital of Cao County，Cao County 274400，China

doi：10.14033/j.cnki.cfmr.2016.24.002

慢性心力衰竭是常见的临床病症，人群中发病率约1.5%～2.0%，在60岁以上的人群中，发生率高达6.0%～10.0%，而且是随着年龄的增加而增加[1]。同时，心力衰竭5年病死率高达50%以上，严重危害着人们的健康。笔者于2012年1月-2016年2月对心力衰竭患者应用阿托伐他汀联合中医中药规范治疗，取得较好临床效果，现报告如下。

1 资料与方法

1.1 一般资料

选择2012年1月-2016年2月于笔者所在医院内科住院的100例慢性心力衰竭患者为研究对象，心功能NY-HA分级Ⅱ～Ⅳ级。其中男52例，女48例，年龄46～82岁，平均（56.3±2.6）岁。随机分为治疗组52例与对照组48例。治疗组52例中，男27例，女25例，年龄46～81岁，平均（57.5±2.8）岁；对照组48例中，男25例，女23例，年龄47～81岁，平均（58.4±2.7）岁，两组患者年龄、性别、心功能分级等一般资料比较差异无统计学意义（P>0.05），具有可比性。……