赵利平 朱晓峰 韩光明 卢路定

【摘要】 目的：觀察基于营养风险评估的个体化营养干预对晚期结直肠癌化疗患者营养状况及生活质量的影响。方法：选择2017年1月-2019年7月在笔者所在医院治疗的108例晚期结直肠癌化疗患者，根据随机数字表法将其分为试验组和对照组，各54例。对照组实施常规营养干预，试验组在对照组基础上实施基于营养风险评估的个体化营养干预。比较两组营养状况、生活质量、营养风险发生率。结果：试验组ALB、PA、Hb水平均高于对照组，差异有统计学意义（P<0.05）。试验组情绪功能、认知功能、社会角色功能、躯体功能评分均高于对照组，差异有统计学意义（P<0.05）。试验组营养风险发生率为18.52%，低于对照组的51.85%，差异有统计学意义（P<0.05）。结论：通过对晚期结直肠癌化疗患者进行基于营养风险评估的个体化营养干预，能显著改善患者的各项营养指标，还能多角度提升患者生活质量，降低营养风险发生率，在临床上具有较高的应用价值。

【关键词】 个性化营养干预 生活质量 营养状况 晚期结直肠癌 营养风险评估

doi：10.14033/j.cnki.cfmr.2020.20.074 文献标识码 B 文章编号 1674-6805（2020）20-0-03

Clinical Study of Individualized Target Nutrition in Patients with Advanced Colorectal Cancer Undergoing Chemotherapy/ZHAO Liping， ZHU Xiaofeng， HAN Guangming， LU Luding. //Chinese and Foreign Medical Research， 2020， 18（20）： -181

[Abstract] Objective： To observe the effect of individualized nutrition intervention based on nutritional risk assessment on nutritional status and quality of life in patients with advanced colorectal cancer undergoing chemotherapy. Method： A total of 108 patients with advanced colorectal cancer undergoing chemotherapy treated in our hospital from January 2017 to July 2019 were selected and divided into the experimental group and the control group according to the random number table method， with 54 cases in each group. The control group received routine nutrition intervention. The experimental group received individualized nutrition intervention based on nutritional risk assessment on the basis of the control group. The nutritional status， quality of life and incidence of nutritional risk of the two groups were compared. Result： The levels of ALB， PA and Hb in the experimental group were higher than those in the control group， the difference was statistically significant （P<0.05）. The scores of emotional function， cognitive function， social role function and physical function in the experimental group were all higher than those in the control group， the differences were statistically significant （P<0.05）. The incidence of nutritional risk in the experimental group was 18.52%， which was lower than 51.85% in the control group， and the difference was statistically significant （P<0.05）. Conclusion： Individualized nutrition intervention based on nutritional risk assessment for patients with advanced colorectal cancer undergoing chemotherapy can significantly improve the patients nutritional indicators， improve the patients quality of life from multiple angles， reduce the incidence of nutritional risk， and has a high clinical application value.

[Key words] Individualized nutrition intervention Quality of life Nutritional status Advanced colorectal cancer Nutritional risk assessment

First-authors address： Yuebei Peoples Hospital， Shaoguan 512000， China

結直肠癌是常见的消化系统恶性肿瘤，早期症状不明显，后期会逐渐出现腹痛、腹部包块、便血等症状，控制肿瘤进展的主要方法是手术、化疗。在进行手术和化疗时，患者的身体机能会大幅度退化，机体分解代谢水平也会升高，易引发营养不良，营养不良反复发作会导致患者机体免疫力降低，形成恶性循环，对治疗效果产生不利影响[1-2]。本研究选择2017年1月-2019年7月在笔者所在医院治疗的晚期结直肠癌化疗患者108例，旨在观察分析基于营养风险评估的个体化营养干预对晚期结直肠癌化疗患者的效果，现报道如下。

1 资料与方法

1.1 一般资料

选择2017年1月-2019年7月在笔者所在医院住院治疗的108例晚期结直肠癌化疗患者作为研究对象。纳入标准：病理学确诊为晚期结直肠癌。排除标准：合并严重消化系统疾病、营养代谢疾病或内分泌疾病者;合并严重脏器功能不全或其他肿瘤者;治疗依从性较差者;化疗耐受性差者。……