彭理平

【摘要】 目的：研究气滞胃痛颗粒联合奥美拉唑和多潘立酮对反流性食管炎效果及对临床症状、生活质量的影响。方法：随机将100例符合入选标准的反流性食管炎患者作为观察对象，平均分成两组，其中对照组50例仅采用奥美拉唑和多潘立酮治疗，观察组50例则在此基础上予以气滞胃痛颗粒治疗。分别对两组治疗后临床效果、治疗前后临床症状及生活质量变化情况进行统计分析。结果：治疗后，观察组治疗总有效率（96.00%）明显高于对照组（78.00%），差异有统计学意义（P<0.05）;观察组临床症状积分明显低于对照组（P<0.05）;观察组生活质量评分明显高于对照组（P<0.05）。结论：对反流性食管炎患者给予气滞胃痛颗粒联合奥美拉唑和多潘立酮治疗，可显著提高临床效果，缓解临床症状，且改善生活质量，可作为临床治疗的有效参考用药。

【关键词】 反流性食管炎 气滞胃痛颗粒 奥美拉唑 多潘立酮 临床症状 生活质量

doi：10.14033/j.cnki.cfmr.2019.29.067 文献标识码 B 文章编号 1674-6805（2019）29-0-03

[Abstract] Objective： To study the effect of Qizhi Weitong Granule combined with Omeprazole and Domperidone on reflux esophagitis and its influence on clinical symptoms and quality of life. Method： A total of 100 patients with reflux esophagitis were randomly divided into two groups. 50 patients in the control group were treated with Omeprazole and Domperidone， and 50 patients in the observation group were treated with Qizhi Weitong Granule on the basis of the control group. The clinical effect， clinical symptoms and quality of life of the two groups before and after treatment were statistically analyzed. Result： After treatment， the total effective rate （96.00%） in the observation group was obvious higher than the control group （78.00%）. The difference was statistically significant （P<0.05）. The clinical symptom scores in the observation group were significantly lower than those in the control group （P<0.05）. And the quality of life score in the observation group was significantly higher than that in the control group （P<0.05）. Conclusion： The treatment of patients with reflux esophagitis with Qizhi Weitong Granule combined with Omeprazole and Domperidone can significantly improve the clinical effect， alleviate the clinical symptoms， and improve the quality of life， and can be used as an effective reference drug for clinical treatment.

[Key words] Reflux esophagitis Qizhi Weitong Granule Omeprazole Domperidone Clinical symptoms Quality of life

First-authors address： Wuhan Huangpi District Peoples Hospital， Wuhan 430300， China

反流性食管炎（RE）屬于临床常见消化系统疾病，多由胃内容物反流至食管，导致食管过度暴露于胃液中，进而引起食管黏膜组织受损，引发反流性食管炎[1]。近年来，我国经济飞速发展，人们的生活水平也日益提高，而且也随着饮食结构的改变，RE发病率呈逐年上升趋势，严重者可引起食管糜烂、溃疡、出血甚至癌变，给人们的生活质量造成严重威胁。因此，找寻合适的药物对疾病的治疗十分关键[2-3]。但目前国内对于气滞胃痛颗粒联合奥美拉唑和多潘立酮治疗反流性食管炎的研究效果尚未见报道。为此，笔者应用气滞胃痛颗粒联合奥美拉唑和多潘立酮治疗RE患者50例，并与单纯应用奥美拉唑和多潘立酮治疗的50例的临床疗效、临床症状、生活质量进行对比，为临床医师提供用药参考。

1 资料与方法