李德君 李慧君

摘 要：目的 探讨来曲唑、苍附导痰汤联合治疗多囊卵巢综合征不孕患者的临床效果。方法 选取我院2015年1月～2016年12月收治的多囊卵巢综合征患者248例，随机双盲法分为试验组和对照组，每组124例。对照组采用口服来曲唑治疗，试验组在对照组治疗基础上服用苍附导痰汤治疗。治疗后观察两组排卵、卵泡未破黄素化综合征（LUFS）和卵巢过度刺激综合征（OHSS）的发生情况，计算各组妊娠率。结果 治疗后试验组排卵数、优势卵泡数分别为（6.23±1.79）个、（6.01±1.83）个，高于对照组的（4.25±0.71）个、（3.93±0.56）个，差异有统计学意义（P<0.05），随访1年后试验组妊娠率为36.29%，高于对照组的25.00%，差异有统计学意义（P<0.05）；试验组LUFS、OHSS发生率分别为9.67%、0.81%，低于对照组的27.42%、4.84%，差异有统计学意义（P<0.05）。结论 来曲唑联合苍附导痰汤能有效促进PCOS患者排卵，增加优势卵泡数，提高妊娠率。

关键词：来曲唑；苍附导痰汤；多囊卵巢综合征；不孕；促排卵

中图分类号：R711.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.043

文章编号：1006-1959（2018）17-0137-04

Abstract：Objective To investigate the clinical effects of letrozole and Cangfu Daotan decoction in the treatment of infertility patients with polycystic ovary syndrome.Methods A total of 248 patients with polycystic ovary syndrome admitted to our hospital from January 2015 to December 2016 were enrolled.The patients were randomly divided into the experimental group and the control group，with 124 patients in each group.The control group was treated with oral letrozole，and the experimental group was treated with Cangfu Daotan decoction on the basis of the control group.After treatment，the incidence of ovulation，follicular unbreaking luteinization syndrome（LUFS）and ovarian hyperstimulation syndrome（OHSS）were observed，and the pregnancy rate of each group was calculated.Results After treatment，the number of ovulation and the number of dominant follicles in the experimental group were（6.23±1.79）and（6.01±1.83），which were higher than those in the control group（4.25±0.71）and（3.93±0.56），the difference was statistically significant（P<0.05），the pregnancy rate of the experimental group was 36.29% after 1 year of follow-up，which was higher than that of the control group 25.00%，the difference was statistically significant（P<0.05）.The incidence of LUFS and OHSS in the experimental group were 9.67% and 0.81 respectively lower than 27.42% and 4.84% of the control group，the difference was statistically significant（P<0.05）. Conclusion Letrozole combined with Cangfu Daotan decoction can effectively promote ovulation in PCOS patients，increase the number of dominant follicles，and increase the pregnancy rate.

Key words：Letrozole；Cangfu Daotan decoction；Polycystic ovary syndrome；Infertility；Ovulation promoting

多囊卵巢綜合征（polycystic ovary syndrome，PCOS）是育龄妇女最为常见的一种内分泌及代谢系统紊乱性疾病，以慢性无排卵和高雄激素血症为特征，临床主要表现为肥胖、多毛、不孕和卵巢囊性增大[1，2]。相关研究表明育龄女性5%～10%患有PCOS，而不孕人群中PCOS比例高达21%，随着现代社会不孕女性发病比例的快速上升，PCOS已成为威胁女性生殖和生理健康的重要因素[3]。目前，PCOS临床治疗主要针对内分泌紊乱和糖代谢异常为靶点，采用药物促进排卵，提高优势卵泡数，从而达到正常妊娠的目的。因此，以2015年1月～2016年12月收治我院的248例PCOS不孕症患者，观察来曲唑、苍附导痰汤联合治疗PCOS的临床疗效，为治疗PCOS不孕症提供科学依据。

1资料与方法

1.1一般资料 选取2015年1月～2016年12月收治新疆佳音医院的248例PCOS不孕症患者为临床研究对象。本研究通过院伦理委员会审核批准。……