莫秋萍++韦汐

DOI：10.16662/j.cnki.1674-0742.2017.09.029

[摘要] 目的 对高敏肌钙蛋白T（hs-cTnT）与慢性心力衰竭的探讨。方法 方便选取医院2015年10月—2016年10月收治的98例慢性心力衰竭患者将其记为疾病组，另选取100名健康志愿者将其记为健康组。对比两组hs-cTnT和N末端脑钠肽原（NT-proBNP）水平，对比疾病组不同心功能分级亚组的hs-cTnT和NT-proBNP水平。结果 疾病组hs-cTnT和NT-proBNP水平远高于健康组[（20.56±4.32）pg/mL vs. （4.02±1.07）pg/mL，（1 167.5±102.4）pg/mL vs.（65.3±10.2）pg/mL，P<0.05]；IV级者hs-cTnT和NT-proBNP水平均显著高于III级者[（29.38±5.54 ）pg/mL vs.（19.25±2.07） pg/mL，（1 548.5±117.8 ）vs. （1 098.7±89.6 ）pg/mL，P<0.05]，且III级者显著高于级者的（8.32±1.14）pg/mL和（469.5±23.7）pg/mL（P<0.05）。 结论 hs-cTnT水平与慢性心力衰竭心脏功能及NT-proBNP水平均存在相关性，对病情评估有重要的意义。

[关键词] 高敏肌钙蛋白T；慢性心力衰竭；相关性

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）03（c）-0029-03

To Explore between the High Sensitivity Cardiac Troponin T and Chronic Heart Failure

MO Qiu-ping， WEI Xi

Department of Cardiovascular Internal Medicine， Liuzhou Peoples Hospital， Liuzhou， Guangxi Province， 545006 China

[Abstract] Objective To explore between the high senstitivity cardiac troponin T and chronic heart failure. Methods 98 cases of patients with chronic heart failure admitted and treated in the hospital from October 2015 to October 2016 were selected as the disease group， and 100 cases of healthy volunteers were selected as the healthy group， and the hs-cTnT and NT-proBNP levels were compared between the two groups， and the hs-cTnT and NT-proBNP levels of subgroups of different cardiac function in the disease group were compared. Results The hs-cTnT and NT-proBNP levels in the disease group were much higher than those in the healthy group[（20.56±4.32） pg/mL vs （4.02±1.07）pg/mL，1 （167.5±102.4）pg/mL vs（65.3±10.2） pg/mL，P<0.05]， and the hs-cTnT and NT-proBNP levels of patients in IV level were obviously higher than those in III level，[（29.38±5.54） pg/mL vs （19.25±2.07） pg/mL，（1 548.5±117.8） vs （1 098.7±89.6） pg/mL，P<0.05]， and the hs-cTnT and NT-proBNP levels of patients in III level were obviously higher than those in II level， and the the hs-cTnT and NT-proBNP levels patients in III level were respectively （8.32±1.14）pg/mL and（469.5±23.7）pg/mL（P<0.05）. Conclusion There is a correlation between the hs-cTnT level， cardiac function of chronic heart failure and NT-proBNP level， which is of important significance to the evaluation of diseases.

[Key words] High senstitivity cardiac troponin T； Chronic heart failure； Correlation

慢性心力衰竭主要是指各种心脏疾病的终末期阶段，该病死亡率高、预后差。近年来随着人们生活压力的增加和老龄化趋势的加重，慢性心力衰竭的发病率明显增高，给社会与家庭带来沉重的医疗负担的同时也严重危及到我国居民的生活质量水平[1]。由此可知，及時探寻灵敏、有效的检测指标以评估患者的病情严重程度并预测预后效果对指导选择有效的治疗方案具有重要的作用和意义。近年来研究显示[2]，N末端脑钠肽原（NT-proBNP）和高敏肌钙蛋白T（hs-cTnT）水平是心力衰竭病情和心脏功能受损严重程度的重要指标，对预后成效也有重要的预测作用。为进一步探讨慢性心力衰竭与hs-cTnT水平的相关性，该研究特将2015年10月—2016年10月该院收治的98例患病者与100名健康者、不同心功能分级者间的hs-cTnT和NT-proBNP水平差异进行对比，现报道如下。

1 资料与方法

1.1 一般资料