冯云++唐海丹

DOI：10.16662/j.cnki.1674-0742.2017.09.101

[摘要] 目的 探讨和分析奥卡西平添加治疗成人难治性癫痫部分性发作的长期疗效与安全性。方法 此次研究方便选择该院在2014年11月—2016年11月期间收治的134例成人难治性癫痫部分性发作患者作为研究主体，依据患者入院顺序均分为甲组和乙组，每组67例患者。甲乙两组患者均保持原有治疗方案，甲组患者加用奥卡西平进行治疗，进行为期12月的观察，对比甲乙两组患者的治疗效果以及不良反应情况。结果 甲组SPS、CPS、SGS患者的治疗有效率（78.57%、77.78%、68.57%）高于乙组（40.00%、43.75%、44.44%），差异有统计学意义（P<0.05）。甲组患者不良反应发生率（29.85%）少于乙组患者（58.21%），差异有统计学意义（P<0.05）。结论 在成人难治性癫痫部分性发作的治疗中添加奥卡西平的长期疗效很好，并且降低了不良反应发生的风险，值得推广。

[关键词] 奥卡西平；难治性癫痫；部分发作；长期疗效；安全性

[中图分类号] R741 [文献标识码] A [文章编号] 1674-0742（2017）03（c）-0101-03

Long-term Curative Effect and Safety of Oxcarbazepine Add-on Therapy for Refractory Partial-onset Seizures in Adults

FENG Yun， TANG Hai-dan

Department of Neurology， Affiliated Hospital of Youjiang Medical College For Nationalities， Baise， Guangxi， 5333000 China [Abstract] Objective To discuss and analyze the long-term curative effect and safety of oxcarbazepine add-on therapy for refractory partial-onset seizures in adults. Methods Convenient selection 134 cases of adult patients with refractory partial-onset seizures admitted and treated in our hospital from November 2014 to November 2016 were selected and divided into two groups with 67 cases in each according to the admission order， both groups preserved the primary treatment plan， the group A added the oxcarbazepine for treatment， and both groups were observed for 12 months， and the treatment effect and adverse reactions situation were compared between the two groups. Results The treatment effective rates of SPS， CPS， SGS patients in the group A were higher than those in the group B， （78.57%， 77.78%， 68.57% vs 40.00%， 43.75%， 44.44%）， and the differences were statistically significant（P<0.05）， and the incidence rate of adverse reactions in the group A was fewer than that in the group B， （29.85% vs 58.21%）， and the difference was statistically significant（P<0.05）. Conclusion The long-term curative effect of oxcarbazepine add-on therapy for refractory partial-onset seizures in adults is good， which can reduce the occurrence risks of adverse reactions， and it is worth promotion.

[Key words] Oxcarbazepine； Refractory epilepsy； Partial seizure； Long-term curative effect； Safety

癲痫是比较常见的一种神经内科系统慢性疾病，主要特征为突然发作性、脑功能暂时性失常，为一种脑功能障碍综合征。经临床实践证实，患者坚持正规药物治疗后，仍有20%患者的发作难以被控制，以部分患者需要长期服药甚至是需终身服药，而且癫痫的发作时间不确定，再加上长期服药易引发多种不良反应，同时人们对癫痫始终存在误解，影响到了患者情绪、心理以及行为，最终导致治疗效果不佳。临床上目前使用的奥卡西平为新型的一种抗癫痫药物，主要以单药治疗报道为主，对于添加治疗的研究报道不多[1]。……