徐宁娜



氯吡格雷及阿司匹林辅助静脉溶栓治疗100例急性心肌梗塞患者的临床分析

徐宁娜

【摘要】目的 对早期嚼服氯吡格雷及阿司匹林联合静脉溶栓治疗急性心肌梗塞临床效果进行分析。方法 选取2013年1月～2016年1月在我院进行静脉溶栓治疗急性心肌梗塞患者200例，随机分为2组，各100例。常规组患者给予常规药物阿司匹林嚼服治疗；改良组患者给予早期嚼服氯吡格雷及阿司匹林联合治疗，对治疗效果进行分析。结果 改良组患者溶栓成功比例优于常规组患者，差异性存在统计学意义（P ＜0．05），对比两组患者的合并症情况，差异无统计学意义（P＞0．05）。两组患者均没有出现死亡情况。结论 对于静脉溶栓治疗急性心肌梗塞的患者早期应用氯吡格雷嚼服及阿司匹林联合治疗，能够增加患者溶栓成功率，减少溶栓操作时间，患者术后合并症的发生比例降低，是理想、科学的静脉溶栓治疗急性心肌梗塞理想的治疗方案。

【关键词】氯吡格雷；阿司匹林；静脉溶栓；急性心肌梗塞

Objective Analysis of the clinical effect of early chewing clopidogrel and aspirin combined with intravenous thrombolysis therapy for acute myocardial infarction． Methods 200 patients with acute myocardial infarction treated by intravenous thrombolysis in our hospital from January 2013 to January 2016 were randomly divided into two groups，100 cases in each． Patients in the conventional group were given conventional aspirin，and the improved group were treated with the combination therapy of early chewing clopidogrel and aspirin． Results The success ratio of the improved group was significantly better than that of the conventional group，and the difference was statistically significant（P＜0．05）． Compared the two groups of patients with complications，the difference was not statistically significant（P＞0．05）． No death occurred in the two groups．Conclusion Early chewing clopidogrel and aspirin combined with intravenous thrombolysis can significantly increase the success rate of thrombolytic therapy for acute myocardial infarction，reduce thrombolysis operation time and the proportion of postoperative complications． It is an ideal and scientific intravenous thrombolytic therapy．

【Key words】Clopidogrel，Aspirin，Intravenous thrombolysis，Acute myocardial infarction

急性心肌梗塞是临床上重症心血管疾病，致病因素较为复杂，主要是冠状动脉急剧减少或中断使得心肌严重而持久的缺血导致心肌坏死［1］。本文选取在我院进行急性心肌梗塞静脉溶栓治疗患者200例，分别给予单纯阿司匹林肠溶片口服治疗和联合氯吡格雷片治疗，详见如下。

1 资料与方法

1.1 一般资料

选取2013年1月～2016年1月在我院进行静脉溶栓治疗急性心肌梗塞患者200例，随机分组，常规组患者100例，其中男性患者49例，女性患者51例，年龄55～74岁，平均年龄（60.50±3.50）岁，病程时间2～6 h，平均病程时间（3.00±1.00）h；……