刘志宇，宋丹丹，张岩丽(齐齐哈尔市精神卫生中心男病房，黑龙江 齐齐哈尔　161000)



扎莱普隆治疗失眠症的疗效观察

刘志宇*，宋丹丹，张岩丽(齐齐哈尔市精神卫生中心男病房，黑龙江 齐齐哈尔161000)

DOI10.14009/j.issn.1672-2124.2016.03.016

摘要目的：分析扎莱普隆对失眠症的临床疗效及安全性。方法：选择齐齐哈尔市精神卫生中心2013年3月—2014年10月收治的98例失眠症患者作为研究对象。按随机数字表法将患者分为观察组50例和对照组48例；观察组患者应用扎莱普隆，对照组患者应用佐匹克隆，比较2组患者的焦虑自评量表(self-rating anxiety scale，SAS)、匹兹堡睡眠质量指数(pittsburgh sleep quality index，PSQI)得分变化情况，临床疗效以及不良反应发生情况。结果：治疗后，观察组患者SAS及PSQI得分分别为(38.35±4.58)、(13.18±5.72)分，显著低于对照组的(41.58±4.62)、(18.52±4.08)分，差异有统计学意义(P<0.05)；观察组患者不良反应发生率为8.00%(4/50)，明显低于对照组患者37.50%(18/48)，差异有统计学意义(P<0.05)；观察组患者总有效率为80.00%(40/50)，高于对照组的75.00%(36/48)，差异无统计学意义(P>0.05)。结论：采用扎莱普隆治疗失眠症不仅安全性好，临床疗效显著，可有效缓解患者焦虑及抑郁情绪。

关键词扎莱普隆； 失眠症； 临床疗效； 安全性

Observation on Efficacy of Zaleplon in Treatment of Insomnia

LIU Zhiyu，SONG Dandan，ZHANG Yanli(Dept.of Male Psychiatric Ward，Qiqihaer Mental Health Center，Heilongjiang Qiqihaer 161000，China)

ABSTRACTOBJECTIVE：To analyze the clinical efficacy and safety of zaleplon in treatment of insomnia. METHODS:98 cases of insomnia admitted into Qiqihaer Mental Health Center from Mar.2013 to Oct.2014 were selected to be divided into observation group(50 cases) and control group(48 cases) via the random number table.The observation group were treated with zaleplon，while the control group received zopiclone，the self-evaluation of anxiety scale(SAS)，Pittsburgh sleep quality index (PSQI) score and clinical efficacy and incidence of adverse drug reactions were compared between two group of patients. RESULTS:After treatment，the SAS and SDS score of observation group were respectively (38.35±4.58) and (13.18±5.72)，significantly lower than that of control group (41.58±4.62) and (18.52±4.08)，with statistically significant difference(P<0.05).The incidence of adverse drug reactions in observation group was 8.00%(4/50)，significantly lower than that in control group 37.50%(18/48)，the difference was statistically significant (P<0.05).Meanwhile，the total effective rate of observation group was higher than that of control group[80.00%(40/50)VS 75.00%(36/48)]，with no statistically significant difference(P>0.05).CONCLUSIONS:The clinical efficacy of zaleplon in treatment of insomnia is not only safe but significant，and can effectively relieve the patients’anxiety and depression.

KEYWORDSZaleplon； Insomnia； Clinical efficacy； Safety

随着现代生活压力的逐渐增加，失眠患者越来越多。根据美国医学界最近的一项研究结果表明，全球的失眠患者占总人数35%[1]。临床上，失眠是指患者因无法入睡导致睡眠质量不高从而影响正常生活的一种现象。这类患者经常表现为对外界声音极度敏感、无法入睡、睡眠质量减低、睡眠时间不够充足，甚至会出现记忆力下降[2]。因此，如何提高患者的睡眠质量成为了现代医学的研究热点。本研究选取齐齐哈尔市精神卫生中心(以下简称“我院”)治疗的98例失眠症患者进行药物治疗，分析扎来普隆的治疗效果，现报告如下。……