胡建高，朱　敏(鄂州市优抚医院精神科，湖北 鄂州　436000)



帕利哌酮注射液治疗首发精神分裂症的疗效观察

胡建高*，朱敏(鄂州市优抚医院精神科，湖北 鄂州436000)

DOI10.14009/j.issn.1672-2124.2016.03.012

摘要目的：观察帕利哌酮注射液治疗首发精神分裂症的临床疗效和不良反应。方法：选择2013年8月—2015年3月期间鄂州市优抚医院收治的81例首发精神分裂症患者作为研究对象，按随机数字表法分为观察组41例与对照组40例。观察组患者应用帕利哌酮注射液治疗，对照组患者应用利培酮片治疗，比较2组患者治疗前后的阳性与阴性症状量表(positive and negative syndrome scale，PANSS)评分及不良反应发生率。结果：2组患者治疗前及治疗5周时PANSS评分比较，差异无统计学意义(P>0.05)；治疗9、17周时，观察组患者的PANSS评分均明显低于对照组，差异有统计学意义(P<0.05)。观察组患者焦虑、心动过速的总发生率为26.8%(11/41)，明显低于对照组65.0%(26/40)，差异有统计学意义(P<0.05)。结论：帕利哌酮注射液治疗首发精神分裂症给药方式更简便，同时不良反应更少，利于患者坚持用药与临床症状改善，效果显著。

关键词帕利哌酮注射液； 精神分裂症； 首发； 不良反应

Observation on the Efficacy of Palipefidone Injection in Treatment of First Episode Schizophrenia

HU Jiangao，ZHU Min(Dept.of Psychiatric，Ezhou Municipal Youfu Hospital，Hubei Ezhou 436000，China)

ABSTRACTOBJECTIVE：To observe the clinical efficacy and adverse drug reactions of paliperidone injection in treatment of first-episode schizophrenia.METHODS:81 cases of first-episode schizophrenia admitted into Ezhou Municipal Youfu Hospital from Apr.2013 to Mar.2015 were selected to be divided into observation group(41 cases) and control group (40 cases) via the random number table. The control group were given palipefidone injection，while the control group received Resperidone tablets；Positive And Negative Syndrome Scale(PANSS) scores and incidence of adverse drug reactions before and after treatment were compared between two group of patients.RESULTS:The comparison of PANSS scores in two groups before treatment and with treatment of 5 weeks was not statistically significant (P>0.05)；with 9 and 17 weeks of treatment，the PANSS scores in observation group was significantly lower than that of control group and the comparison between two groups was statistically significant (P<0.05).The incidence of anxiety and tachycardia in observation group was significantly lower than that in control group，and the total incidence rate was 26.8%(11/41)which was significantly lower than 65.0%(26/40)in control group and the comparison was statistically significant (P<0.05).CONCLUSIONS:Palipefidone injection in treatment of first episode schizophrenia is more convenient，with few adverse drug reactions，which is conducive to patients’adherence of medication and the improvement of clinical symptoms. The effects are remarkable.

KEYWORDPaliperidone； Schizophrenia； First episode； Adverse drug reactions

精神分裂症具有高复发、慢性迁延性等特点，此外受到服药依从性低等因素影响，该病治疗难度较大[1]。美国有研究对1种典型及4种常见非典型抗精神分裂症口服药物进行统计[2]，结果显示，治疗18个月期间内，74%患者出现过药物中断情况，而药物中断原因分析结果中，给药频繁太麻烦及药物不良反应居前2位，提示坚持用药也成为精神分裂症临床治疗需重视问题。基于这一情况，有国外专家提出，精神分裂症临床用药需同时具备非典型及长效抗精神病药物优势[3]，疗效才可获得进一步提高。本研究以鄂州市优抚医院(以下简称“我院”)收治首发精神分裂症患者为研究对象，对帕利哌酮注射液治疗首发精神分裂症的临床疗效和不良反应进行观察，现报告如下。