李裕兴，雷国大，李伟恒(广东省怀集县人民医院药剂科，广东 肇庆　526400)



3种他汀类药物治疗冠心病的成本-效果分析

李裕兴*，雷国大，李伟恒(广东省怀集县人民医院药剂科，广东 肇庆526400)

DOI10.14009/j.issn.1672-2124.2016.03.024

摘要目的：比较瑞舒伐他汀钙片、阿托伐他汀胶囊及阿托伐他汀钙片治疗冠心病的成本-效果。方法：选取2013年6月—2015年12月收治的150例冠心病患者作为研究对象，按随机数字表法分为A、B、C组，每组50例。A组患者采用阿托伐他汀钙片进行治疗，B组患者采用阿托伐他汀胶囊进行治疗，C组患者采用瑞舒伐他汀钙片进行治疗，分析3组患者的血脂变化水平，并比较疗效及经济效益。结果：治疗后，3组患者的血脂均较治疗前显著下降，差异有统计学意义(P<0.05)。A组患者的总有效率为86.00%(43/50)，B组的总有效率为84.00%(42/50)，C组的总有效率为88.00%(44/50)，3组的差异无统计学意义(P>0.05)。A组患者的治疗总成本为1 619.2元，B组为934.4元，C组为1 177.6元，B组的总成本最低；A组患者的的成本-效果比为18.75，B组为9.12，C组为14.47，B组的成本-效果比最低。结论：阿托伐他汀胶囊可有效控制冠心病患者的血脂水平，且成本相对较低，值得临床推广。

关键词他汀类药物； 冠心病； 成本-效果分析

Cost-effectiveness Analysis onThree Kinds of Statin-related Drugsin Treatment ofCoronary Heart Disease

LI Yuxing, LEI Guoda, LI Weiheng(Dept.of Pharmacy, Guangdong Huaiji County People’s Hospital, Guangdong Zhaoqing 526400, China)

ABSTRACTOBJECTIVE：To compare the cost-effectiveness of Rosuvastatin calcium tablets, Atorvastatin calcium capsules and Atorvastatin calcium tablets in treatment of coronary heart disease. METHODS: 150 cases of coronary heart disease admitted from Jun. 2013 to Dec. 2015 were selected to be divided into group A, group B and group C via the random number table, with 50 cases in each. Group A were treated with Rosuvastatin calcium tablets, group B received Atorvastatin calcium capsules and group C were given Atorvastatin calcium tablets; the changes of blood lipid level of 3 group of patients were analyzed; the efficacy and economic efficiency were compared. RESULTS: After treatment, the blood lipid level of 3 groups were significantly decreased compared with before treatment, the difference was statistically significant (P<0.05). The total effective rate of group A, group B and group C were respectively 86.00%(43/50), 84.00%(42/50) and 88.00%(44/50), with no statistically significant difference(P>0.05). The total cost of group A was 1 619.2 yuan, group B was 934.4 yuan and group C was 1 177.6 yuan; the lowest total cost was group B. Meanwhile, the cost - effectiveness ratio of group A was 18.75, group B was 9.12 and group C was 14.47; the lowest one was group B. CONCLUSIONS: Atorvastatin calcium capsules can effectively control the blood liquid level of patients with coronary heart disease, with relatively lowcost. It is worthy of clinical promotion and application.

KEYWORDSStatin-related drugs; Coronary heart disease; Cost -effectiveness analysis

目前，他汀类降脂药由于具有较好的耐受性、安全性，且疗效较好而被广泛应用于临床[1-3]。多数医院将其作为防治冠心病的基础药物之一。但是，由于本类药物需要长期服药，影响家庭贫困患者的长期接受治疗[4-7]。本研究选取150例冠心病患者作为研究对象，采用3种不同的他汀类药物进行治疗，并对3种药物进行成本-效果分析，以期为临床用药提供更加经济、有效、安全的用药方案，现报告如下。……