裴玉焕

【摘 要】目的：观察双歧杆菌四联片与抗生素对小儿腹泻的疗效及对免疫功能的影响。方法：选取我院收治的98例患儿，随机分为观察组和对照组各49例。通过对两组实施不同方案后，比较两组患儿临床相关指标以及免疫功能相关指标水平。结果：观察组各临床指标与对照组相比，均明显缩短（P<0.05） ；治疗前，两组患儿IgG、IgA水平对比均无显著差异（P>0.05），治疗后，观察组患儿IgG与IgA水平均显著高于对照组。结论：双歧杆菌活菌片与抗生素对小儿腹泻具有重要的临床疗效，能提高患儿免疫力，有效缩短患儿腹泻持续时间和住院时间，值得临床推广应用。

【关键词】小儿腹泻；益生菌；临床疗效；免疫功能

Clinical efficacy and immune function of Bifidobacterium tetralogy viable tablets combined with antibiotics in children with diarrhea

Pei Yuhuan

LiaochengShuicheng maternity hospital，Shangdong Province，Shandong Liaocheng 252000，China

【Abstract】Objective： To investigate the clinical efficacy and immune function of Bifidobacterium tetralogy viable tablets combined with antibiotics in children with diarrhea. Methods： 98 children with diarrhea addmitedin our hospital were randomly divided into observation group and control group，with 49 cases in each group， After implementing different schemes for the two groups， the levels of clinical related indexes and immune function related indexes of the two groups were compared. Results： the clinical indexes in the observation group were significantly shorter than those in the control group（P<0.05）； Before treatment， there was no significant difference in the levels of IgG and IgA between the two groups（P>0.05）. After treatment， the levels of IgG and IgA in the observation group were significantly higher than those in the control group.Conclusion： the clinical value of Bifidobacterium quadruple viable tablets combined with antibiotics for infantile diarrhea is prominent. It can effectively shorten the duration of diarrhea and hospital stay， and significantly improve the immune function of children. It is worthy of clinical application.

【Key？Words】Infantile diarrhea； Probiotics； Clinical efficacy； Immunity

腹泻是临床常见的一种症状的统称，特别好发于5岁以下儿童，发病率高达20.1%[1]。引发该疾病发生的因素多种多样，不仅可引发患儿排便规律改变，严重时易出现严重脱水与电解质紊乱，危及生命健康。临床工作中多采用抗菌、补液及止泻药对患儿进行治疗，取得一定的疗效。但是，对患儿肠道菌群的维护能力欠佳。随着当今社会对微生态认知的不断提高，微生态制剂对肠道菌群的重建具有较好的效果[2]。我们对腹泻患儿应用双歧杆菌四联片与抗生素治疗，现报道如下。

1 资料与方法

1.1 一般资料

选择我院2020 年3月至2021年4月收治的98例腹泻患儿为研究主体，随机分为两组各49例。对照组，女性21例，男性28例，年龄4岁～6岁，平均年龄（5.84±0.98）岁；观察组，女性23例，男性26例，年龄4岁～6岁，平均年龄（5.93±1.25）岁。两组一般资料比较，差异不显著（P>0.05）。

1.2 方法

对照组予以一般治疗方案：改善内环境、补液、适量的阿莫西林克拉维酸钾（武汉医药有限公司，H2089557801）及蒙脱石散（杭州龙达新科制药厂，H200894503）。研……