白彩云

【摘 要】目的：探究对罹患未足月胎膜早破孕妇应用抗生素治疗时间对母婴结局的实际影响。方法：对100例罹患未足月胎膜早破孕妇予以选取，收集患者时间段为2019年4月至2021年4月间，对照組（胎膜早破至抗生素给药时长大于12小时）和观察组（胎膜早破至抗生素给药时长在12小时内）各50例，就两组产妇、婴儿不良结局、孕周延长时间、新生儿Apgar评分等评估结果加以对比分析。结果：在治疗工作展开后，两组新生儿7d内感染发生概率没有实质性区别（P>0.05）；观察组产后出血、产褥感染和绒毛膜羊膜炎发生概率均显著低于对照组（P<0.05），而孕周延长时间和新生儿Apgar评分与对照组相比均明显居更高水平（P<0.05）。结论：对未足月胎膜早破孕妇尽早予以抗生素治疗，可有效改善母婴结局，预防不良结局的发生，可在临床上推广应用。

【关键词】未足月胎膜早破；抗生素应用时间；母婴结局；Apgar评分

The effect of antibiotic application time on maternal and infant outcome in the treatment of preterm premature rupture of membranes

Bai Caiyun

Department of Obstetrics， peoples Hospital of HuzhuTu Autonomous County， Qinghai Haidong 810599，China

【Abstract】Objective：To explore the actual effect of antibiotic treatment time on maternal and infant outcomes for pregnant women suffering from preterm premature rupture of membranes.Methods：100 pregnant women suffering from preterm premature rupture of membranes were selected.The time period for collecting patients was from April 2019 to April 2021.The control group （the time from premature rupture of membranes to antibiotic administration was more than 12 hours）and the observation group （the duration from premature rupture of membranes to antibiotic administration within 12 hours），50 cases in each group，the two groups of maternal， infant outcome，prolonged gestational week， newborn Apgar score and other evaluation results were compared and analyzed.Results：After the start of treatment，there was no substantial difference in the incidence of infection within 7 days between the two groups of newborns （P>0.05）；the incidence of postpartum hemorrhage，puerperal infection and chorioamnionitis in the observation group were significantly lower than those in the control group（P<0.05）， while the prolonged gestational weeks and the Apgar score of newborns were significantly higher than those of the control group（P<0.05）. Conclusion：Early antibiotic treatment for pregnant women with preterm premature rupture of membranes can effectively improve the maternal and infant outcomes and prevent the occurrence of adverse outcomes. It can be promoted and applied in clinical practice.

【Key？Words】Preterm premature rupture of membranes； Antibiotic application time； Maternal and infant outcome； Apgar score

未足月胎膜早破是指产妇在孕周小于37周时胎膜发生自然破裂的现象。如果不及时接受治疗，严重者很可能会造成胎儿窘迫、新生儿感染等不良现象[1]。根据以往学者的临床总结，抗生素治疗的实施对未足月胎膜早破的母婴结局有很好的改善效果，但理论研究相对较少，因此对于抗生素的最佳应用时机仍需要临床研究并加以验证[2]。基于此本研究随机纳入我院妇产科过往接收的共100例未足月胎膜早破产妇作为研究对象，考察在破膜后的不同时间点对其施以抗生素治疗对母婴结局的实际影响。研究具体情况赘述如下。

1 资料及方法

1.1 基本资料

随机截选未足月胎膜早破产妇100例，均为我院妇科于2019年4月至 2021年4月接收，按就诊顺序排列随机分组。观察组50例，年龄22岁～38岁，平均年龄（29.33±1.08）岁，孕周28周～34周，平均孕周（31.25±0.28）周；对照……