黄庭 胡聪

[摘要] 目的 探讨银杏叶片联合左西孟旦治疗慢性心力衰竭的临床疗效。 方法 选取2018年1月至2019年12月我院收治的慢性心衰患者366例，随机分为观察组和对照组，每组各183例。对照组给予左西孟旦治疗，观察组在对照组基础上联用银杏叶片， 比较两组患者的左室射血分（LVEF）、左室舒张末径（LVED）、血清内皮素（ET-1）、N末端B型利钠肽原（NT-proBNP），比较两组临床疗效。 结果 治疗前，两组患者LVEF、LVED、NT-proBNP和ET-1比较，差异无统计学意义（P>0.05）;治疗后，两组患者的LVED、LVEF明显升高，NT-proBNP、ET-1显著降低（P<0.05），且观察组优于对照组（P<0.05）。观察组总有效率为90.16%，对照组为67.21%，两组比较，差异有统计学意义（P<0.05）。 结论 银杏叶片联合左西孟旦可明显改善心力衰竭患者的临床症状，改善其心功能，临床疗效较优，临床应用价值较高。

[关键词] 银杏叶片;左西孟旦;慢性心力衰竭;临床疗效

[中图分类号] R514.6          [文献标识码] B          [文章编号] 1673-9701（2021）08-0050-03

Clinical study of ginkgo leaf tablet combined with levosimendan in treatment of chronic heart failure

HUANG Ting   HU Cong

Department of Cardiology，the First Affiliated Hospital of Nanchang University， Nanchang   330006， China

[Abstract] Objective To explore clinical efficacy of ginkgo leaf tablet combined with levosimendan in treatment of chronic heart failure（CHF）. Methods A total of 366 patients with CHF admitted to our hospital from January 2018 to December 2019 were selected as research objects and they were randomLy divided into the observation group（n=183） and the control group（n=183）. The control group was treated with levosimendan and the observation group was treated with ginkgo leaf tablet on the basis of the control group. Left ventricular ejection fraction（LVEF）， left ventricular end diastolic（LVED）， serum endothelin（ET-1）， N-terminal pro-B-type natriuretic peptide（NT-proBNP） and the clinical efficacy were compared between two groups. Results Before treatment， there was no significant difference between two groups in LVEF， LVED， NT-proBNP and ET-1（P<0.05）， but LVED， LVEF significantuy increased， NT-proBNP and ET-1 significantly decreased after treatment in both groups and those indicators in the observation group were better than those in the control group（P<0.05）.The total effective rate of the observation group was 90.16%， and that of the control group was 67.21%， with statistically significant differences（P<0.05）. Conclusion Ginkgo leaf tablet combined with levosimendan can improve clinical symptoms and cardiac function of patients with CHF， with a good clinical efficacy and application value.

[Key words] Ginkgo leaf tablet; Levosimendan; Chronic heart failure; Clinical efficacy

慢性心力衰竭，簡称慢性心衰，是诸多心血管疾病晚期的临床状态[1-2]。慢性心力衰竭患者生活质量较差，预后不良，近年来，该病治疗有了诸多进展，目前临床上治疗采用β-受体激动剂和磷酸二酯酶抑制剂等正性肌力药物，虽取得一定疗效，但其可诱发心律失常等不良反应，病死率并未降低。故在长期临床应用中受到一定局限[3]。随着左西孟旦的上市，其具有改善慢性心衰临床症状的同时又不增加心肌耗氧量和改善心功能的优点，因此受到临床的广泛关注[4]，但在实际临床治疗中发现部分患者仅用左西孟旦给药后并不能较好控制病情，疗效欠佳，提示需联用其他辅助药物，对药物的选择和合理使用一直是研究的重点[5-6]。中医治疗慢性心衰具有明显特色，在治疗心力衰竭中发挥重要作用，可明显减轻不良反应，保护靶器官。银杏叶片来源于银杏，具有活血化瘀之功效，主要包括抑制血管炎症、扩张动脉及促进血液循环等药理作用[7]。目……