葛校枫

【摘要】 目的 观察丁苯酞联合他汀类药物治疗缺血性脑血管病的临床疗效及对神经功能的影响。方法 98例缺血性脑血管病患者， 采用随机数字表法分为对照组与实验组， 各49例。对照组患者实施他汀类药物治疗， 实验组患者实施丁苯酞联合他汀类药物治疗。比较两组患者的治疗效果及治疗前后美国国立卫生研究院卒中量表（NIHSS）评分、Barthel指数。 结果 治疗后， 两组患者NIHSS评分均低于治疗前， Barthel指数均高于治疗前， 且实验组患者NIHSS评分（11.07±2.06）分低于对照组的（14.86±3.17）分， Barthel指数（14.42±1.87）分高于对照组的（11.77±1.22）分， 差异有统计学意义（P<0.05）。实验组患者临床治疗总有效率为93.88%， 对照组患者临床治疗总有效率为75.51%;实验组患者临床治疗总有效率明显高于对照组， 差异具有统计学意义（P<0.05）。结论 针对缺血性脑血管病采用丁苯酞联合他汀类药物进行治疗， 可明显改善患者的神经功能缺损情况及日常生活能力， 提升临床疗效， 效果理想。

【关键词】 丁苯酞;他汀类药物;缺血性脑血管病;神经功能

DOI：10.14163/j.cnki.11-5547/r.2020.20.047

【Abstract】 Objective   To observe the clinical efficacy butylphthalide combined with statins in the treatment of ischemic cerebrovascular disease and its influence on nerve function. Methods   A total of 98 patients with ischemic cerebrovascular disease were divided into control group and experimental group by random numerical table， with 49 cases in each group. The control group was treated by statins， and the experimental group was treated by butylphthalide combined with statins. The therapeutic effect， National Institutes of Health stroke scale （NIHSS） score and Barthel index before and after treatment were compared between the two groups. Results   After treatment， NIHSS score of the two groups was lower than that before treatment， and Barthel index was higher than that before treatment. After treatment， NIHSS score （11.07±2.06） points of the experimental group was lower than that of the control group （14.86±3.17） points， Barthel index （14.42±1.87） points was higher than that of the control group （11.77±1.22） points， and the difference was statistically significant （P<0.05）. The total effective rate of clinical treatment of the experimental group was 93.88%， which was 75.51% of the control group. The total effective rate of clinical treatment of the experimental group was obviously higher than that of the control group， and the difference was statistically significant （P<0.05）. Conclusion   For the treatment of ischemic cerebrovascular disease， butylphthalide combined with statins can significantly improve neurological score， activities of daily living and clinical therapeutic effect of patients， and the effect is ideal.

【Key words】 Butylphthalide; Statins; Ischemic cerebrovascular disease; Nerve function

由于腦部血循环障碍造成的缺氧、缺血， 所致局部脑组织缺血性坏死， 称为缺血性脑血管病。患者通常会有明显的征兆， 如突发头晕、口齿不清、口角歪斜， 身体局部麻木， 乏力、行走不稳等， 这些症状可维持几分钟至数小时， 但由于患者对该疾病缺乏认知， 不能及时进行治疗[1， 2]。尽管溶栓及血管内治疗目前仍是脑梗死的一线治疗方式， 但由于许多患者症状较轻， 不能引起患者及家属的关注， 错过了溶栓时间窗， 因此通过抗血小板、抗凝、降纤、改善微循环、活血化瘀等治疗改善局部缺血区域的血液流变学， 由此改善局部脑灌注[3]。缺血性脑血管病的发病特点为易反复发作且病死率较高， 因此无论采取何种治疗手段其幸存者普遍存在神经功能缺损情况。基于此， 本文以丁苯酞联合他汀类药物对缺血性脑血管病进行治疗， 以此探讨临床疗效， 报告如下。……