孔顺利 马艳红

[摘要] 目的 就頸动脉狭窄患者应用阿托伐他汀联合阿司匹林治疗方案展开分析，探讨临床效果及实际应用价值 方法 方便选取2018年9月—2019年9月来该院治疗就诊的颈动脉狭窄患者70例作为调查对象，按照患者入院顺序单双号随机分为观察组和对照组。观察组应用阿托伐他汀联合阿司匹林进行药物治疗，对照组仅实施阿司匹林进行药物治疗。收集两组患者治疗前后临床资料，分析相关生理指标，开展回顾性分析。结果 观察组左颈总动脉内膜中层厚度为（1.19±0.08）mm，左颈内动脉中层厚度为（1.27±0.16）mm，右颈总动脉内膜中层厚度（1.47±0.14） mm，右颈内动脉中层厚度为（1.35±0.13）mm，各项指标均优于对照组，差异有统计学意义（P<0.05）;观察组患者治疗满意度为94.28%（33/35），优于对照组74.28%（26/35），差异有统计学意义（P<0.05）;观察组不良反应发生率17.14%（6/35），优于对照组48.57%（17/35），差异有统计学意义（P<0.05）。结论 颈动脉狭窄患者使用阿托伐他汀联合阿司匹林，能够有效提高脑血管流量，降低脑补短暂性缺血和复发脑梗死等重大疾病发生率，有效减低颈部重要血管中的内膜厚度，降低患者血脂水平并保持稳定，对肝肾也无较大的毒副作用。

[关键词] 颈动脉狭窄;阿托伐他汀;阿司匹林;临床效果

[Abstract] Objective To analyze the application of atorvastatin combined with aspirin treatment in patients with carotid artery stenosis， and to explore the clinical effect and practical value. Methods The method is to treat patients with carotid artery stenosis convenient celection in the hospital from September 2018 to September 2019. 70 cases were investigated， and patients were randomly divided into observation group and control group according to the order of admission. The observation group was treated with atorvastatin combined with aspirin for drug treatment， and the control group was treated with only aspirin for drug treatment. Collect clinical data before and after treatment in two groups of patients， analyze relevant physiological indicators， and conduct retrospective analysis. Results In the observation group， the thickness of the medial layer of the left common carotid artery was （1.19±0.08） mm， the thickness of the medial layer of the left carotid artery was （1.27±0.16） mm， and the thickness of the medial layer of the right common carotid artery was （1.47±0.14） mm. The thickness of the middle layer of the artery was （1.35±0.13） mm， and all indicators were better than the control group， the difference was statistically significant （P<0.05）; the treatment satisfaction of the observation group was 94.28% （33/35） It was better than the control group by 74.28%（26/35）， and the difference was statistically significant（P<0.05）; the incidence of adverse reactions in the observation group was 17.14% （6/35）， which was better than the control group by 48.57%（17/35）， the difference was statistically significant（P<0.05）.Conclusion Atorvastatin combined with aspirin in patients with carotid stenosis; can effectively increase cerebral vascular flow; reduce the incidence of major diseases such as transient cerebral ischemia and recurrent cerebral infarction; effectively reduce the intimal thickness of important neck blood vessels; the blood lipid level remains stable; it has no major toxic and side effects on liver and kidney.

[Key words] Carotid stenosis; Atorvastatin; Aspirin; Clinical effect

颈动脉是脑部供血的重要血管，颈动脉狭窄在临床表现来看，有较大几率出现缺血性脑卒中、脑梗死等神经性疾病[1]。现阶段，颈动脉狭窄患者主要通过合理有效的药物治疗控制病情恶劣进展，但是由于不良反应及并发症发生率在治疗过程中仍然有一定風险出现，致残率和病死率较高，所以在临床用药讨论方面，应用他汀类药物能够有效治疗颈动脉狭窄或粥样硬化斑块形成，有效调节患者血脂水平，降低机体低密度脂蛋白、甘油三酯，减低总胆固醇[2]。文章方便选取2018年9月—2019年9月来该院治疗就诊的颈动脉狭窄患者70例作为调查对象，探究阿托伐他汀联合阿司匹林治疗颈动脉狭窄患者的临床效果。……