张囡囡 邱娥 张颜芳

[摘要] 目的 探讨对造血干细胞移植后口腔粘膜炎患者采用短波紫外线辅助治疗的效果。方法 研究对象方便选取该院2017年1月—2019年2月收治的异基因造血干细胞移植后出现口腔粘膜炎的78例患者，根據随机数字表法分为对照组（n=39）和观察组（n=39）。对照组患者予以常规治疗，观察组患者在其基础上予以短波紫外线治疗。观察两组患者治疗2周后口腔溃疡愈合效果、治疗前后疼痛程度及口腔溃疡愈合时间。结果 观察组患者治疗后口腔溃疡痊愈率（94.87%）较对照组患者口腔溃疡痊愈率（76.92%）高，差异有统计学意义（χ2=5.186，P<0.05）;观察组患者治疗1、2周后疼痛缓解程度分别为（3.21±0.88）分、（1.20±0.12）分，较对照组显著，两组比较差异有统计学意义（t=4.728、29.664，P<0.05）;观察组患者溃疡面积缩小>50%（4.32±0.59）及溃疡面愈合时间（10.25±1.20）d均较对照组短，两组比较差异有统计学意义（t=21.142、5.398，P<0.05）。 结论 对造血干细胞移植后口腔粘膜炎患者采用短波紫外线辅助治疗可提高口腔溃疡愈合效果、缓解疼痛、加快溃疡创面愈合时间。

[关键词] 口腔粘膜炎;短波紫外线;造血干细胞移植;愈合效果

[Abstract] Objective To investigate the effect of short-wave ultraviolet adjuvant therapy on patients with oral mucositis after hematopoietic stem cell transplantation. Methods The study subjects convenient selected 78 patients who developed oral mucositis after allogeneic hematopoietic stem cell transplantation in the hospital from January 2017 to February 2019. They were divided into control group（n=39） and observation group （n=39） according to the random number table method. Patients in the control group were treated conventionally， and patients in the observation group were treated with short-wave ultraviolet. To observe the effect of oral ulcer healing， the degree of pain before and after treatment， and the healing time of oral ulcer in two groups of patients. Results The healing rate of oral ulcers in the observation group （94.87%） was higher than that in the control group （76.92%）. The difference between the two groups was statistically significant（χ2=5.186， P<0.05）. The degree of pain relief after 1 and 2 weeks were （3.21±0.88） points and （1.20±0.12） points， respectively， which were more significant than the control group， and the difference between the two groups was statistically significant （t=4.728， 29.664， P<0.05）; The ulcer area in the observation group was reduced by more than 50% （4.32±0.59） and the healing time of the ulcer surface（10.25±1.20）d was shorter than that in the control group. The difference between the two groups was statistically significant（t=21.142， 5.398， P<0.05）. Conclusion The use of short-wave ultraviolet adjuvant therapy for patients with oral mucositis after hematopoietic stem cell transplantation can improve the healing effect of oral ulcers， relieve pain， and speed up the healing time of ulcer wounds.

[Key words] Oral mucositis; Short-wave ultraviolet; Hematopoietic stem cell transplantation; Healing effect

口腔粘膜炎是造血干细胞移植过程中最常见的并发症。其出现的口腔粘膜屏障损伤易引发细菌感染而造成菌血症等不良反应将严重威胁患者生命[1]。故合理治疗口腔粘膜炎至关重要。目前对于口腔粘膜炎多采用复方氯己定等漱口液漱口，局部涂贝复济等生长因子治疗，但治疗周期长且不能达到理想效果。短波紫外线治疗是通过局部照射小剂量紫外线促进组织修复、加快创面愈合的治疗方式[2]。故该研究将该院2017年1月—2019年2月收治的异基因造血干细胞移植后出现口腔粘膜炎的78例患者分别采用常规治疗和短波紫外线辅助治疗，并对其治疗效果、疼痛缓解程度及口腔溃疡创面愈合时间对比观察，现报道如下。……