辜强

【摘要】 目的：分析β-受體阻滞剂在心力衰竭治疗中的应用。方法：本次研究对象选取笔者所在医院于2016年10月-2018年12月收治的100例心力衰竭患者，随机分为对照组（50例）和试验组（50例），对照组患者接受常规药物治疗，试验组患者在接受常规药物治疗的基础上接受β-受体阻断剂药物治疗，对比两组患者的治疗效果、生存质量评分、心功能指标及不良反应发生情况。结果：试验组患者的临床总有效率为96.00%，而对照组患者的临床总有效率为78.00%，比较差异有统计学意义（P<0.05）;试验组患者的生存质量评分显著高于对照组患者，差异有统计学意义（P<0.05）;试验组患者的心功能指标显著优于对照组患者，差异有统计学意义（P<0.05）;试验组患者的不良反应发生率为14.00%，而对照组患者的不良反应发生率为10.00%，比较差异无统计学意义（P>0.05）。结论：心力衰竭患者接受β-受体阻断剂治疗后的疗效显著，其生存质量有所改善，且心功能指标也有所改善，安全性更高，值得临床推广。

【关键词】 β-受体阻断剂; 心力衰竭; 不良反应; 生存质量; 心功能指标; 治疗效果

doi：10.14033/j.cnki.cfmr.2019.27.017 文献标识码 B 文章编号 1674-6805（2019）27-00-03

Application of β-blockers in the Treatment of Heart Failure/GU Qiang.//Chinese and Foreign Medical Research，2019，17（27）：-41

【Abstract】 Objective：To analyze the application of β-blockers in the treatment of heart failure.Method：One hundred patients with heart failure who were admitted to our hospital from October 2016 to December 2018 were randomly divided into the control group（50 cases） and the experimental group（50 cases）.The control group received conventional drugs.Patients in the experimental group received β-blocker drug therapy on the basis of conventional drug therapy.And the treatment effect，quality of life score，cardiac function index and adverse reaction occurred in the two groups were compared.Result：The total clinical effective rate of the experimental group was 96.00%，while the total effective rate of the control group was 78.00%，the difference of the data was statistically significant（P<0.05）.The survival quality score of the experimental group was significantly higher than the control group，the difference was statistically significant（P<0.05）.The heart function index of the experimental group was significantly better than that of the control group，the difference was significant（P<0.05）.The incidence of adverse reactions in the experimental group was 14.00%，the incidence of adverse reactions in the control group was 10.00%，and the difference was not significant（P>0.05）.Conclusion：The patients with heart failure have significant curative effect after receiving β-blockers.The quality of life has improved，and the cardiac function index has improved.It is safer and worthy of clinical promotion.

【Key words】 β-receptor blocker; Heart failure; Adverse reactions; Quality of life; Cardiac function index; Therapeutic effect

First-authors address：Qianjiang Hospital Affiliated to Renmin Hospital of Wuhan University，Qianjiang 433100，China

临床上心力衰竭是一种较为严重的心血管疾病，其是心脏功能或结构异常所导致的射血能力和心室充盈受损的临床綜合征，是心脏疾病的终末阶段[1]。其受多种因素的影响，患者心脏的收缩功能和舒张功能均会出现障碍，导致心脏的排血量下降，机体的正常生理要求无法得到满足，主要临床表现为呼吸困难、水肿和喘息，会对患者的日常生活产生影响[2]。在给予心力衰竭患者临床治疗时，常采用抗心力衰竭药物，但是治疗的效果不甚理想，而β-受体阻断剂成为心力衰竭患者的常规用药，其可以通过抑制交感神经以抑制心室重构，从而改善心力衰竭的症状，并且有利于患者的预后康复，且β-受体阻断剂有利于降低心力衰竭患者的病死率和再住院率[3-4]。……