黄青丽 李堃 王汉卫

【摘要】目的研究早期联合应用七叶皂苷钠﹑低分子肝素钠治疗急性脑梗死的疗效及安全性。方法将80例发病6～24 h内的急性脑梗死患者随机分成治疗组和对照组各40例，对照组单纯使用低分子肝素钠治疗，治疗组在对照组治疗基础上加用七叶皂苷钠治疗，并于治疗前后评定两组患者的临床疗效及神经功能缺损程度评分（NDS）。结果治疗组的临床疗效明显优于对照组，NDS评分较对照组明显降低，差异有统计学意义（P<0.05）。结论急性脑梗死早期联合应用七叶皂苷钠与低分子肝素钠进行治疗，疗效比单纯应用肝素钠更好，不良反应少而且安全。

【关键词】七叶皂苷钠；肝素；早期；急性脑梗死

中图分类号：R743.33 文献标识码：ADOI：10.3969/j.issn.10031383.2018.02.013

Clinical observation of sodium aescinate combined with lowmolecularweight

heparin sodium for the early stage of acute cerebral infarction in 40 cases

HUANG Qingli1， LI Kun1，WANG Hanwei2

（1.Development of Pharmacy，2.Department of Internal Medicine，Peoples Hospital of Youjiang District，Baise 533000，China）

【Abstract】ObjectiveTo study the efficacy and safety of sodium aescinate combined with lowmolecularweight heparin sodium for the early stage of acute cerebral infarction.Methods80 patients with acute cerebral infarction within 6～24 hours of onset were randomly divided into treatment group （n=40） and control group （n=40）.The control group were treated with lowmolecularweight heparin sodium alone，and based on which the treatment group were added sodium aescinate.And then，clinical efficacy and neurofunctional defect score（NDS） of the two groups were evaluated before and after treatment.ResultsThe clinical efficacy of the treatment group was significantly better，and the NDS score was significantly lower than that of the control group，difference was statistically significant（P<0.05）.ConclusionSodium aescinate combined with lowmolecularweight heparin sodium for the early stage of acute cerebral infarction is more effective than heparin sodium alone with less adverse reactions and high safety.

【Key words】sodium aescinate；heparin；early stage；acute cerebral infarction

急性脑梗死又叫急性缺血性脑卒中，是最常见的卒中类型，占全部脑卒中的60%～80%，早期一般是指发病6～24 h内。该病发病率一直在不断上升，是人类死亡的主要原因之一[1]。早期诊断、早期治疗、早期康复、早期预防再发是临床上处理急性脑梗死的重要原则。目前，临床上为了使急性脑梗死患者血栓扩大得到有效的控制及溶解血栓，从而改善脑血液循环，并使患者神经功能缺损尽可能降低，主要采用溶栓、抗凝、降纤、改善循环、神经保护等方法[2]。我院自2012年1月至2015年12月对40例确诊为急性脑梗死患者早期即采用七叶皂苷钠联合低分子肝素钠治疗，取得良好疗效，现总结报道如下。

1资料与方法1.1一般资料入选标准：发病6～24 h非昏迷者；无出血性疾病及明顯出血倾向者；瘫痪肢体肌力3级以下；无近期大手术、创面未愈合者；无过敏体质；无昏迷；无严重肝肾疾病者。经筛选符合入围患者80例，其中男45例，女35例，将患者随机分为治疗组40例与对照组40例。……