林文 薛秋美 陈美蓉

[摘要] 目的 探討文拉法辛联合利培酮应用于精神病性抑郁症患者中的临床疗效以及对患者SDS评分的影响。方法 方便选取2015年1—12月在该院进行治疗的74例精神病性抑郁症患者作为研究对象，并将其按照随机数字法分成观察组37例与对照组37例，观察组患者给予文拉法辛联合利培酮治疗，对照组患者仅给予单一的利培酮治疗，分别对两组患者的临床疗效、抑郁（SDS）评分及不良反应进行对比。结果 观察组患者在抑郁症状、精神病情症状上的治疗有效率为86.5%、89.2%，对照组患者在抑郁症状、精神病情症状上的治疗有效率为83.8%、86.5%，两组患者的临床疗效差异无统计学意义（P>0.05）；观察组患者的SDS评分（15.9±3.3）分明显低于对照组患者的SDS评分（28.6±5.7）分；观察组患者的不良反应发生率明显低于对照组患者。结论 文拉法辛联合利培酮与单一的利培酮治疗均能在精神病性抑郁症中取得显著疗效，但文拉法辛联合利培酮治疗的起效更快、不良反应更少，具有更高的临床应用价值。

[关键词] 文拉法辛；利培酮；精神病性抑郁症；SDS评分

[中图分类号] R749 [文献标识码] A [文章编号] 1674-0742（2018）01（a）-0149-03

Clinical Effect of Venlafaxine Combined with Risperidone in the Treatment of Psychotic Depression and Its Effect on SDS Score of Patients

LIN Wen1， XUE Qiu-mei2， CHEN Mei-rong3

1.Outpatient and Emergency Department， Fuzhou Neuropsychiatric Therapeutic Hospital， Fuzhou， Fujian Province， 350008 China； 2.Department of Neurology and Psychiatry， Fuzhou Neuropsychiatric Therapeutic Hospital， Fuzhou， Fujian Province， 350008 China； 3.Department of Outpatient， Fuzhou Neuropsychiatric Therapeutic Hospital， Fuzhou， Fujian Province， 350008 China

[Abstract] Objective This paper tries to investigate the clinical efficacy of venlafaxine combined with risperidone in patients with psychotic depression and its effect on SDS score. Methods A total of 74 patients with psychotic depresson who were treated in this hospital from January to December 2015 were conveniently enrolled in this study. 37 patients were divided in the observation group and control group respectively according to the random number method. The observation group was treated with venlafaxine combined with risperidone and the control group received only single risperidone treatment. The clinical efficacy， depression（SDS） score and adverse reactions were compared between the two groups. Results The effective rate of treatment in the observation group was 86.5% and 89.2% of depressive symptoms and mental illness. The effective rate was 83.8% and 86.5% in the patients in the control gorup with depressive symptoms and mental illness，the different were not statistically significant（P>0.05）. The SDS score in the observation group was （15.9±3.3）points， significantly lower than that in the control group of （28.6±5.7）points. The incidence of adverse reactions in the observation group was significantly lower than that in the control group. Conclusion Venlafaxine combined with risperidone and single risperidone can achieve a significant effect in psychotic depression， but venlafaxine combined with risperidone has a faster onset and fewer adverse effects， which has a higher clinical value.

[Key words] Venlafaxine； Risperidone； Psychotic depression； SDS score

临床常用的利培酮作为治疗精神病性抑郁症的首选药物[1]，该药物具有较好的抗抑郁与抗焦虑效果，有学者为进一步提高精神病性抑郁症的临床疗效提出文拉法辛与利培酮的联合治疗[2]，该次研究为了探究文拉法辛联合利培酮应用于精神病性抑郁症患者中的实际疗效以及对患者的抑郁症状影响，就该院2015年1—12月收治的74例精神病性抑郁症患者分别给予文拉法辛联合利培酮治疗与单一的利培酮治疗进行研究，现报道如下。