邓有才++++++刘红梅++++++贾乙++++++张建祥++++++李晓辉++++++唐渊

[摘要] 生物药剂学与药物动力学是药学类专业的核心课程之一，其实验教学能使学生巩固和扩展理论教学内容，培养学生的自主学习和原始创新能力。建构主义认为，学习是在特定的情景下，通过协作和会话，实现新旧知识之间融合的意义建构。第三军医大学药学系药剂学教研室在建构主义理论的指导下，开展了生物药剂学与药物动力学综合性实验教学改革。以临床实际问题作为教学情境，通过“教师之间”“学生之间”“师生之间”三个方面的协作和会话，使学生在自主解决问题的过程中掌握相关的知识，实现知识的意义建构。

[关键词] 生物药剂学与药物动力学；建构主义；综合性实验；教学改革

[中图分类号] R642 [文献标识码] A [文章编号] 1673-7210（2017）06（a）-0130-04

Teaching reform of comprehensive experiment of biopharmaceutics and pharmacokinetics based on constructivism theory

DENG Youcai LIU Hongmei JIA Yi ZHANG Jianxiang LI Xiaohui TANG Yuan

Department of Pharmaceutics， College of Pharmacy， Third Military Medical University， Chongqing 400038， China

[Abstract] Biopharmaceutics and pharmacokinetics is one of the core curricula of pharmacy students and its experimental teaching can enable students to consolidate and expand theoretical teaching content， cultivate students' autonomous learning and the ability of original innovation. Constructivism is a theory to explain how knowledge is constructed in the human being when information comes into contact with existing knowledge by special circumstances， cooperation， conversation and meaning construction. Department of Pharmaceutics， College of Pharmacy， Third Military Medical University carried out the teaching reform of comprehensive experiment of biopharmaceutics and pharmacokinetics based on constructivism theory， used clinical practical problems as the cases in teaching situation， and carried out three aspects of cooperation and conversation between teachers and students. The teaching reform of comprehensive experiment helps students solve problems independently and achieve the ultimate goal of the construction of meaning.

[Key words] Biopharmaceutics and pharmacokinetics； Constructivism； Comprehensive experiment； Teaching reform

生物藥剂学与药物动力学主要研究药物及其剂型在体内的吸收、分布、代谢与排泄过程，并应用动力学原理和数学方法，对药物进入体内后量时变化或血药浓度经时变化进行定量描述[1]。生物药剂学与药物动力学为药学类专业学生的核心专业课程之一，已在我国大部分高等医药院校药学专业和药剂学专业本科开设。该课程既是一门包含复杂数学运算的理论性学科，更是一门具有强烈实践需求的综合性和应用性学科。实验教学是生物药剂学与药物动力学的重要组成部分，不仅能使学生巩固和扩展理论教学内容，掌握学科的基本知识和基本理论，而且可以培养学生的独立观察、发现问题和解决问题能力，提升学生的自主学习和原始创新能力[2-3]。……