周景成

[摘要] 目的 研究八正散联合三金汤治疗泌尿系结石的临床疗效。 方法 选择2013年1月～2015年6月在我院就诊的62例泌尿系结石患者作为研究对象，将其随机分为对照组与实验组，各31例。对照组口服消石素治疗；实验组采用八正散联合三金汤的治疗方法，根据患者的病情在八正散联合三金汤的治疗基础上加减治疗，治疗3个疗程后比较两组患者的临床疗效和不良反应发生情况。 结果 对照组患者治疗总有效13例（41.94%），实验组29例（93.55%），实验组总有效率显著高于对照组，差异有统计学意义（P<0.05）。实验组患者不良反应发生率为9.68%，对照组为32.26%，实验组不良反应发生率明显低于对照组，差异有统计学意义（P<0.05）。结论 八正散联合三金汤治疗泌尿系结石疾病临床疗效显著，不良反应发生率低，安全性高，值得临床推广应用。

[关键词] 泌尿系结石；八正散；三金汤；临床疗效；不良反应

[中图分类号] R277.5 [文献标识码] A [文章编号] 1674-4721（2016）03（c）-0110-03

[Abstract] Objective To study the clinical efficacy of eight positive powder combined with Sanjin decoction in the treatment of urinary calculi. Methods 62 patients with urinary calculi in our hospital from January 2013 to June 2015 were chosen as study objects and were randomly divided into the control group and the observation group，each group had 31 cases.The control group patients was treated Niter Su，the observation group patients was treated eight positive powder combined with Sanjin decoction，the patients were given addition and subtraction treatment on the basis of eight positive powder combined with Sanjin decoction depending on the patient′s condition，the clinical efficacy and the incidence of adverse reactions after three courses of treatment between the two groups was compared. Results The total effective of the control group patients was 13 cases（41.94%），the total effective of the observation group patients was 29 cases（93.55%），the total effective rate of the observation group was obviously higher than that of the control group，the difference was statistically significant（P<0.05）.The total incidence of adverse reactions of the experimental group was 9.68%，32.26% in the control group，the incidence of adverse reactions of the experimental group was obviously lower than that of the control group，the difference was statistically significant（P<0.05）. Conclusion Eight positive powder combined with Sanjin decoction in the treatment of urinary calculi has significant clinical effect and the treating method is very safety，the incidence of adverse reactions is significantly low，which is worthy of clinical application on urinary calculi.

[Key words] Urinary calculi；Eight positive powder；Sanjin decoction；Clinical efficacy；Adverse reaction

泌尿系结石疾病为临床常见、多发病，在中医理论中归属“石淋”范畴[1]，其疾病机制为膀胱与肾气化不利[2]。结石的形成与产生是由于患者尿液pH值发生改变、尿酸盐分泌与代谢紊乱、晶体与基质之前的平衡破坏等状况下产生沉淀并逐渐累积形成结石。结石的形成可导致泌尿系感染、梗阻、损伤等病理改变，严重影响患者的生活质量[3]。在中医学中，八正散具有利水通淋、清热泻火的功效；三金汤可行气止痛、清热化湿、凉血止血之功能[4]，两者联合应用治疗泌尿系结石的临床疗效显著。本实验选取在我院就诊的62例泌尿系结石患者为研究的对象，旨在探讨八正散联合三金汤治疗泌尿系结石的临床疗效。

1 资料与方法

1.1 一般资料

选取2013年1月～2015年6月在我院就诊的62例泌尿系结石患者作为研究对象，所有患者均经肾盂造影或B超检查确诊患有泌尿系结石。……