罗宇东++++++蒋林++++++朱智德++++++陈洪涛

[摘要] 目的 通过大鼠30 d喂养试验，探讨六味葛蓝降脂片的安全性。 方法 选取80只大鼠，随机分为3个剂量组和1个对照组（共4组），每组20只，雌、雄各10只。剂量组给予15.0、10.0、5.0 g/（kg·BW）的剂量（人体可能摄入量的150、100、50倍），对照组灌服等体积蒸馏水，每天灌胃1次，连续30 d后对大鼠各项指标进行观察。 结果 各剂量组与对照组在试验过程中均生长良好，无死亡，未发现异常体征。各剂量组的体重增长率、食物利用率、血液学指标、血液生化指标、脏/体比值等指标与对照组比较，差异无统计学意义（P>0.05）。 结论 在本实验的剂量范围内，六味葛蓝降脂片大鼠30 d喂养未见短期的毒副作用。

[关键词] 六味葛蓝降脂片；毒理学安全性；实验研究

[中图分类号] R-332 [文献标识码] A [文章编号] 1674-4721（2016）03（c）-0015-04

[Abstract] Objective To explore the safety of Liuwei Gelan Lipid-decreasing tablet by 30-day feeding in rats. Methods 80 rats were selected and randomly divided into 3 groups with dosages and the control group.Male and female rats were equally divided.In these dosage groups，15.0，10.0 and 5.0 g/（kg·BW） were provided，which were 150，100 and 50 times of dosages taken by human body.In the control group，the same volume of distilled water was supplied.Gavage was performed once per day.The each index from rats was observed and tested after 30 continuing days of experiment. Results Rats were all well grown without death in the process of experiment in the control group and each dosage group.No abnormal sign was detected.There was no significant difference in the weight growth rate，food utilization rate，haematological inde，hematologic and biochemical indices，viscera/body ratio between these among 3 dosage groups and the control group （P>0.05）. Conclusion Within dosages tested in the experiment，no short-term toxic and side effect is detected after 30-day feeding in rats by Liuwei Gelan Lipid-decreasing tablets.

[Key words] Liuwei Gelan Lipid-decreasing tablet；Toxicological safety；30-day feeding

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