刘学博

[摘要] 目的 探讨HPV感染与宫颈癌的关系，为宫颈癌的筛查提供临床参考。 方法 收集2012年9月～2014年10月在我院就诊的宫颈癌患者200例，将其根据是否存在HPV感染分为HPV感染组和无HPV感染组，HPV感染组再分为单一感染组和多重感染组。 结果 单一感染率、多重感染率分别为60.0%、11.0%。单一感染率最高为HPV16，其次为HPV18、HPV58，其余亚型均<2%。多重感染以二重感染为主，且以HPV16±58比例最高。在所有HPV感染中，大多数为含HPV16亚型的感染。多重感染组患者年龄与单一感染组比较差异无统计学意义（P>0.05）。多重感染组≥55岁的比例明显高于单一感染组（P<0.05），两组病理类型均以鳞癌为主，病理分期均以浸润癌为主，差异无统计学意义（P>0.05）；两组淋巴结转移率差异无统计学意义（P>0.05）。 结论 HPV感染与宫颈癌存在一定关系，这可能对宫颈癌的筛查、预后有指导作用。

[关键词] HPV多重感染；HPV单一感染；宫颈癌

[中图分类号] R711.74 [文献标识码] A [文章编号] 1674-4721（2016）03（c）-0132-03

[Abstract] Objective to study the relationship between HPV infection and cervical cancer to provide clinical reference for cervical cancer screening. Methods 200 patients with cervical cancer treated in our hospital from September 2012 and October 2014 were collected.According to whether there was HPV infection，they were divided into HPV infection group and non HPV infection group，HPV infection group was further divided into single infection group and multiple infection group. Results The single infection rate and multiple infection rate was 60.0%，11.0% respectively.The single highest infection rate was HPV16，followed by HPV18，HPV58 once again，the other subtypes were less than 2%.Multiple infections was mainly double infection，and the percentage of HPV16±58 was the highest.Among all HPV infection，the majority was the subtype of HPV16 infection.There was no statistical difference of age between multiple infection group and single infection group （P>0.05）.The proportion of more than 55 years old in multiple infection group was obviously higher than that of single infection group （P<0.05）.Pathological type of 2 groups were mainly squamous cell carcinoma，pathological staging were invasive carcinoma，the difference was not statistically significant （P>0.05）；there was no statistical difference of lymph node metastasis rate between two groups （P>0.05）. Conclusion There is a certain relationship between HPV infection and cervical cancer，which may have a guiding role for screening and prognosis of cervical cancer.

[Key words] HPV multiple infection；HPV single infection；Cervical cancer

宫颈癌是女性生殖系统最常见的一种恶性肿瘤，其对女性生命健康造成严重影响。人乳头状瘤病毒（HPV）感染对宫颈癌的发生起关键性作用已被大量研究所证实，它具有多种亚型，目前已知的有120种，根据感染状态，HPV感染分为单一亚型感染和多重感染（2种亚型以上的感染）[1]。二重感染和三重感染是最常见的多重感染类型。许多研究表明，多重感染与宫颈病变间有密切的相关性，是宫颈病变和宫颈癌发生的独立危险因素[2]。本研究收集200例宫颈癌患者，对其进行HPV感染监测，分析HPV感染与患者临床特征的关系，以期为宫颈癌的筛查及防治提供临床依据。

1 资料与方法

1.1 一般资料

收集2012年9月～2014年10月在我院就诊的宫颈癌患者200例，所有患者术前均接受HPV检测及术后病理确诊。患者年龄21～76（46.2±8.6）岁。根据是否存在HPV感染分为HPV感染组和无HPV感染组，并将HPV感染组细分为单一感染组和多重感染组。