赵芬　张岩波　刘近春

[摘要] 现代医疗模式的转变，使越来越多的学者意识到仅靠传统的临床疗效评价指标评价药物疗效及选择治疗方案存在很多不足。因此，近年来患者的生存质量备受关注，患者对疾病的主观感受、对治疗效果的评价成为临床决策中的重要指标。而在生存质量基础上发展而来的患者报告结局（patient reported outcomes，PRO），使患者可以参与到诊疗过程中。近年来，很多学者将生存质量与PRO应用于癌症研究中的多个方面，并研制出了许多相关量表。本文主要就生存质量与PRO的研究现状及其在胃癌研究中的应用作一简单概述。

[关键词] 胃肿瘤；患者报告结局；生活质量；量表

[中图分类号] R735.2 [文献标识码] A [文章编号] 1673-9701（2015）32-0157-04

[Abstract] With the transformation of modern medical model， more and more scholars realize that there are many disadvantages only relying on indexes of the traditional clinical effects evaluation to evaluate the effects of drugs and the choice of therapeutic regimen. So many people pay more attention to the quality of life of patients in recent years. The directly feel of disease from patients， the evaluation of treatment response from patients become the important indexes of clinical decision-making. PRO which is based on quality of life makes patients have a chance to really involve in medical treatment process. Quality of life and PRO is applied to many aspects of cancer research in recent years， and scholars have developed a number of related scales. This article will give a brief introduction about present study and application in the study of gastric cancer of quality of life and patient peported outcomes.

[Key words] Stomach neoplasm； Patient reported outcomes； Quality of life； Scale

随着医学模式及疾病谱的转变，人们逐渐意识到威胁人类健康不仅是传染病，更值得关注的是癌症及心脑血管疾病等慢性病。癌症疾病本身及其各种治疗方法给患者身体带来痛苦的同时，对其心理及家庭生活也造成了不容忽视的负担，胃癌也不例外[1]。胃癌（gastric carcinoma）是世界范围内最常见的恶性肿瘤之一，目前仍是世界上第二大癌症死因。胃癌患者期望的不仅是延长自己的寿命，还有生活质量的提高[2]。因此，仅用传统的实验室及影像学等客观指标评价胃癌的治疗效果有限，应选择一个包含个人躯体、心理和社会等多个维度的综合指标。近40年来，健康相关生活质量量表被广泛应用于数以万计的患者及各种癌症患者[3]。患者作为医疗服务的中心，其主观感受在健康评价中的作用越来越重要。……