反复呼吸道感染与血清IgA含量及免疫功能变化分析
2015-03-24冯海红
冯海红
[摘要] 目的 探讨和评价反复呼吸道感染患儿血清IgA含量变化和免疫功能影响。 方法 选择2013年1月~2014年10月在本院接受治疗的52例反复呼吸道感染患儿为研究对象,对这52例患儿在治疗期间的血清IgA含量变化和免疫功能影响指标进行详细观察与记录,与另外选择的50例健康儿童进行比较,研究其关系。 结果 反复呼吸道感染组血清IgA含量为(0.89±0.75) g/L、血清IgG含量为(7.43±3.15) g/L、CD3+浓度为(61.35±6.07)%、CD4+浓度为(30.52±3.72)%;健康儿童组血清IgA含量为(1.69±0.82) g/L、血清IgG含量为(9.88±3.97) g/L、CD3+浓度为(69.89±5.39)%、CD4+浓度为(39.85±3.09)%;差异有统计学意义(P<0.05)。 结论 反复呼吸道感染患儿血清IgA含量和免疫功能均低于健康儿童,其可为临床治疗提供相应依据。
[关键词] 反复呼吸道感染;血清IgA含量;免疫功能;影响分析
[中图分类号] R562.2 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0030-03
Analysis on the change of recurrent respiratory tract infection and the content of IgA in serum and immune function
FENG Hai-hong
Department of Pediatrics,Luoyang Shihua Hospital of Luoyang City,Luoyang 471012,China
[Abstract] Objective To explore the change of recurrent respiratory tract infection and the content of IgA in serum and immune function. Methods 52 patients with recurrent respiratory tract infection treated in our hospital from January 2013 to October 2014 were selected,the change on the content of IgA in serum and immune function during the treatment was observed and recorded.50 healthy children were selected,correlation was studied. Results The content of IgA in recurrent respiratory tract infection group was(0.89±0.75) g/L,the serum IgG content was(7.43±3.15) g/L,the concentration of CD3+ was(61.35±6.07)%,the concentration of CD4+ was(30.52±3.72)%;the content of IgA in healthy children group was(1.69±0.82) g/L,the serum IgG content was(9.88±3.97) g/L,the concentration of CD3+ was(69.89±5.39)%,the concentration of CD4+ was(39.85±3.09)%;with statistical difference between two groups(P<0.05). Conclusion The content of IgA in serum and immune function in children with recurrent respiratory tract infection is lower than that of healthy children,it can provide corresponding evidence for clinical treatment.
[Key words] Recurrent respiratory tract infection;Serum IgA level;Immune function;Effect analysis
反复呼吸道感染[1]指一年以内发生上、下呼吸道感染的次数过于频繁,超过一定范围的呼吸道感染,是小儿常患疾病之一,且不受季节和地域的影响,发病时间都比较长,在发病初期如果没有得到及时有效的治疗,将会对小儿呼吸系统的正常发育产生严重影响[2-3],给小儿的生命质量带来消极影响。临床治疗上认为该疾病之所以不断复发,与小儿自身免疫力密切相关,本研究主要探讨反复呼吸道感染患儿免疫功能和血清IgA与病情的关系,同时与健康儿童进行对比分析,以期为临床实践提供依据。
1 资料与方法
1.1 一般资料
收集本院2013年1月~2014年10月收治的反复呼吸道感染患儿52例,其中男性30例,女性22例;年龄11个月~6岁,平均(2.5±0.5)岁;体重5.5~28 kg,平均(22.5±8.7) kg;3个月内有15例发病2次,16例发病3次,19例发病4次,2例发病5次。另外选择50例健康儿童,其中男童30例,女童20例,平均年龄(3.5±1.5)岁。……
