林凤姬

[摘要]目的 分析反復呼吸道感染患儿血清维生素A的水平及维生素A水平对患儿免疫功能的影响。方法 选取2014年1月～2015年6月我院收治的100例反复呼吸道感染儿童作为本研究的观察组，并将同期在我院接受健康体检的100名正常儿童作为对照组。将观察组的患儿分为观察组1（n=40）和观察组2（n=60），观察组患儿均采取常规抗感染治疗，对观察组1的患儿还给予维生素A补充治疗。采用微量荧光法、自动生化分析仪对观察组和对照组儿童的维生素A、IgA、IgM、IgG水平进行测定。比较治疗前观察组与对照组患儿的维生素A、IgA、IgM、IgG水平，比较观察组1和观察组2患儿的临床治疗总有效率以及治疗前后的IgA、IgM、IgG水平。结果 与对照组比较，观察组患儿的维生素A、IgM、IgG和IgA水平明显降低（P<0.01）；观察组1的临床治疗总有效率显著高于观察组2（P<0.05）；治疗前观察组1和观察组2的IgA、Igm和IgG水平比较，差异无统计学意义（P>0.05），治疗后观察组1的IgA、Igm和IgG水平显著高于观察组2（P<0.01）。结论 反复呼吸道感染患儿的血清维生素A水平低于健康儿童，因此对于反复呼吸道感染的患儿采用维生素A补充治疗能够增强患儿的免疫功能，获得更加显著的治疗效果。

[关键词]反复呼吸道感染；维生素A；免疫功能

[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-4721（2017）01（c）-0074-03

[Abstract]Objective To analyze the changes of serum vitamin A levels in children with recurrent respiratory tract infection and its effects on immune function.Methods 100 cases of children with recurrent respiratory tract infection treated in our hospital from January 2014 to June 2015 were selected as the study group，and 100 healthy children in our hospital were taken as control group.The observation group was divided into observation group 1（n=40） and observation group 2（n=60）.Children in the observation group were treated with conventional anti-infective therapy and the observation group 1 received vitamin A supplementation in addition.The levels of vitamin A and immune function of children in the control group were measured by microfluorescence，flow cytometry and automatic biochemical analyzer.The total effective rate of clinical treatment and the levels of IgA，IgM and IgG before and after treatment were compared between observation group 1 and observation group 2.Results The levels of vitamin A，IgA，IgM and IgG in the observation group were significantly higher than those in the control group（P<0.01）.The total effective rate of clinical treatment in the observation group 1 was significantly higher than that in the observation group 2（P<0.01）.There was no significant difference in the levels of IgA，IgM and IgG before treatment between observation group 1 and observation group 2（P>0.05）.After treatment，Serum levels of IgM，IgG and IgA in observation group 1 were significantly higher than those in the observation group 2（P<0.01）.Conclusion Children with recurrent respiratory tract infection have a lower level of serum vitamin A than healthy children.Vitamin A supplementation therapy for children with recurrent respiratory tract infection can enhance children′s immune function，get more significant therapeutic effect.

[Key words]Repeated respiratory infections；Vitamin A；Immune function

反复呼吸道感染在小儿疾病中较为常见，该病的病因跟机体免疫功能的变化情况有着密切的联系[1]。维生素A是人体营养所需，其可以促进身体的健康发育、调控机体的组织细胞分化以及增殖，且对维持血清中的细胞免疫活性发挥着重要的效果[2]。人体一旦缺失维生素A，即会影响正常的生长和发育，引起疾病，发生失明等，还会对患儿机体的免疫功能造成损害，对患儿本人甚至家庭都造成不良影响。相关基础实验结果显示，稳定的维生素A水平可以维持大鼠的正常抗体水平，因而，对儿童予以合理剂量的维生素A十分有必要，可以发挥免疫佐剂的作用[3]。……