李红

【摘要】目的：探讨治疗脑器质性精神障碍的方法及效果。方法：回顾性分析我院2013年1月~12月收治的脑器质险精神障碍60例患者临床资料，随机分为观察组和对照组各30例，观察组给予口服利培酮口服液进行治疗，对照组患者给予奥氮平进行治疗，比较和分析两组的治疗效果。结果：观察组患者的总有效率为80.0%，对照组为83.4%，比较两组患者的总有效率无明显差异（P＞0.05），无统计学意义。两组治疗1周后及治疗4周后的PANSS量表总分均明显低于治疗前（P＜0.05），具有统计学意义，组间比较无明显差别（P＞0.05），无统计学意义。结论：采用奥氮平与利培酮治疗脑器质性精神障碍，均具有较高的临床效果，并且具有较低的不良反应发生率，对改善预后、提高患者生活质量具有显著疗效，值得临床推广应用。

【关键词】奥氮平；利培酮；脑器质性精神障碍

Comparative analysis of olanzapine and risperidone in the treatment of brain organic mental disorder

【Abstract】Objective: To explore the method and effect for treatment of brain organic mental disorder. Methods: retrospective analysis of brain organic mental disorders risk in our hospital in 2013 January ~12 months in 60 patients clinical data, were randomly divided into observation group and control group with 30 cases in each group, the observation group was given oral Risperidone Oral Solution treatment, the control group were treated with olanzapine for treatment, comparison and analysis of the therapeutic effect of the two groups. Results: the patients in the observation group the total effective rate was 80%, 83.4% in the control group, compared two groups of patients there were no significant difference (P > 0.05), no statistical significance. The two groups after 1 weeks and 4 weeks after the treatment, the PANSS scores were significantly lower than those before therapy (P < 0.05), with statistical significance, there is no obvious difference between the groups (P > 0.05), no statistical significance. Conclusion: Olanzapine and risperidone in the treatment of brain organic mental disorder with clinical effect, have a higher incidence of adverse reactions, and has lower, to improve the prognosis, and has obvious curative effect and improve the life quality of patients, is worthy of clinical application.

【Key words】Olanzapine; Risperidone; brain organic mental disorder

【中图分类号】R453【文献标识码】A 【文章编号】2095-6851（2014）06器质性精神障碍(Organic psychosis)是指各种脑器质性精神病、躯体疾病和中毒引起的可逆性或不可逆性脑功能损害时所致的精神障碍。目前，临床治疗脑器质性精神障碍多采用奥氮平与利培酮两种药物。为了研究奥氮平和利培酮治疗脑器质性精神障碍的临床效果，笔者选取我院2013年1月~12月收治的脑器质险精神障碍60例，进行分组治疗，比较和分析两组的治疗效果。报告如下。

1资料与方法

11一般资料

选取我院2013年1月~12月收治的脑器质险精神障碍60例患者为研究对象。符合《中国精神障碍分类与诊断标准》第3版（CCMD3）脑器质险精神障碍诊断标准，入组前未服用任何抗精神病药，均经患者及家属知情同意。排……