王昌阳　慈军　吴萼

[关键词] 纤维蛋白原;突发性耳聋;血栓弹力图;平均血小板体积

[中图分类号] R764.4          [文献标识码] B          [文章编号] 1673-9701（2021）18-0065-04

Clinical value of MPV， FG and TEG in diagnosis and treatment of sudden deafness in adults

WANG Changyang1   CI Jun1   WU E2

1.Department of Otorhinolaryngology， Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine， Hangzhou 310000， China; 2.Medical College of Hangzhou Normal University， Hangzhou 310000，China

[Abstract] Objective To explore the value of fibrinogen（FG）， mean platelet volume（MPV） and thromboelastography（TEG） in the diagnosis and treatment of sudden deafness in adults. Methods A total of 96 adult patients with sudden deafness admitted to our hospital from February 2018 to November 2019 were selected as the observation group， and 85 healthy subjects were selected as the control group. The levels of MPV， FG， TEG and blood lipid were compared between the two groups. The levels of MPV， FG， TEG， blood lipid and hearing threshold of the observation group were compared before treatment and after 7 days of treatment. Results The hearing threshold of observation group was significantly improved to （49.89±9.65）dB after 7 days of treatment compared with （71.21±10.75）dB before treatment;MPV and FG values in the observation group were （11.56±0.41） FL and （2.98±0.82）g/L， which were higher than （10.46±0.43）FL and （2.47±0.53）g/L in the control group; the R value of TEG （5.46±0.13） was higher than （5.96±0.31） of the control group， and the TG level of blood lipid （1.93±0.36）mmol/L was higher than （1.31±0.12）mmol/L of the control group（P>0.05）. There were significant differences in MPV， FG， TEG and blood lipid levels between before treatment and 7 days after treatment in the observation group （P<0.05）. Conclusion The blood lipid level， MPV， FG， TEG are related to sudden deafness and hearing， which have application value in clinical diagnosis and treatment.

[Key words] Fibrinogen; Sudden deafness; Thromboelastography; Mean platelet volume

突發性耳聋病因不明，为耳科常见疾病，指72 h内突然发生的，不明原因的听力下降，表现为两个及以上相邻频率的听力下降>20 dB[1]。患者不仅听力下降，还可伴耳鸣、耳闷、眩晕，影响患者生活。相关研究指出，突发性耳聋出现原因与内耳微循环障碍、血流淤滞、微血栓形成密切相关[2]。血小板在外源或内源性作用下发生聚集、黏附、释放反应，是血栓、止血重要环节。血栓疾病会引起纤维蛋白原（Fibrinogen，Fg）、平均血小板体积（Blood platelet，MPV）的升高，血液会存在高凝状态。血栓弹力图（Thromboela-stogram，EG）可动态监测纤溶、凝血的整个过程，反应凝血过程中各部分之间关系及作用[3]。本文以96例患者开展研究，以65例健康患者对照，观察MPV、Fg、TEG各指标在突发性耳聋患者中变化，现报道如下。

1 资料与方法

1.1  一般资料

选取2018年2月至2019年11月我院就诊的96例成年突发性耳聋为观察组。纳入标准[4]：①符合突发性耳聋诊断标准[5]，且年龄≥18岁，经我院确诊;②均为首次发病，入院前未接受相关治疗;③患者均知晓本研究，自愿签署知情同意书。排除标准[6]：①严重心、肝、脑、肾等疾病，恶性肿瘤、中毒性耳聋、梅尼埃病、听神经瘤;②其他疾病所致耳聋，血液系统疾病、凝血障碍等;③患有传染性疾病、糖尿病、冠心病、高血压等疾病。对照组为我院体检的85例健康患者，经体检无耳部障碍、无基础疾病。观察组男51例，女45例，年龄22～62岁，平均（37.12±5.13）岁;对照组男47例，女38例，年龄21～64岁，平均（38.15±4.96）岁。两组……