庞婷婷 陈绍鹏 谭鲲

[摘要]目的通過探讨不同频率同时单采血小板和新鲜冰冻血浆制备的冷沉淀质量比较，探讨采血间隔期设置是否科学。方法随机选取湛江市中心血站2019年1月至2020年1月献血者800例，根据首次和连续多次两个月、一个月、半个月一次同时单采血小板和新鲜冰冻血浆分为四组，每组各200例，检测其单采新鲜冰冻血浆制备成冷沉淀后的Ⅷ因子和纤维蛋白原（FIB）含量，观察Ⅷ因子、FIB 含量不合格率，并进行统计学分析。结果一个月一次、半个月一次的Ⅷ因子和 FIB 含量明显低于首次对照组、两个月一次，差异有统计学意义（ P <0.05），两个月一次与首次对照组比较，差异无统计学意义（ P >0.05）;一个月一次、半个月一次Ⅷ因子含量不合格率与首次对照组比较，差异有统计学意义（ P <0.01），半个月一次的 FIB 含量不合格率与首次对照组比较，差异有统计学意义（ P <0.01），其余频率采集Ⅷ因子、FIB 含量不合格率与首次对照组比较，差异无统计学意义（ P >0.05）。结论不同频率同时单采血小板采集血浆制备冷沉淀的质量存在差异，一个月或半个月一次捐献后制备冷沉淀的Ⅷ因子含量较质量标准有明显差异。一个月、半个月一次单采血小板献血者不建议其同时捐献新鲜冰冻血浆，避免对献血者健康造成影响。

[关键词]单采血小板;新鲜冰冻血浆;Ⅷ因子;纤维蛋白原

[中图分类号] R457  [文献标识码] A   [文章编号]2095-0616（2021）24-0015-03

Quality comparison of cryoprecipitate prepared by simultaneous apheresis platelet and fresh frozen plasma at different frequencies

PANG  Tingting    CHEN  Shaopeng    TAN  Kun

Department of Quality Control， Zhanjiang Blood Center， Guangdong， Zhanjiang 524002， China

[Abstract] Objective To compare the quality of cryoprecipitate prepared by collecting fresh frozen plasma from apheresis platelets with different frequencies， and to explore the scientificity of the interval setting of blood collection. Methods A total of 800 blood donors were randomly selected from January 2019 to January 2020 in Zhanjiang Blood Center， and they were divided into four groups according to the first and continuous collection of platelets and fresh frozen plasma for once every two months， one month and half a month， with 200 people in each group. The content of factor Ⅷ and fibrinogen （FIB） was detected after cryoprecipitate was prepared from fresh frozen plasma， observe the unqualified rate of factor Ⅷ and FIB content. The statistical analysis was conducted. Results The Ⅷ factor and FIB content of once a month and half a month was significantly lower than that of the first control group and once every two months， the difference was statistically significant （P <0.05）， but there was no significant difference between once every two months and the first control group （P >0.05）.Once a month and a half month Ⅷ fraction defective is compared with the first control group was statistically significant （P <0.01）， a half month FIB content is not qualified rate compared with the first control group was statistically significant （P <0.01）， the rest of the frequency acquisition Ⅷ factor， fraction defective FIB content compared with the first control group without statistical significance （P >0.05）. Conclusion There are differences in the quality of cryoprecipitate prepared by collecting plasma from platelets at different frequencies， and the content of factor Ⅷ in cryoprecipitate prepared by donating once a month or half a month is significantly different from the quality standard. Blood donors who collect platelets once a month or half a month are not recommended to donate fresh frozen plasma at the same time， so as to avoid affecting the health of blood donors.

[Key words] Apheresis platelets; Fresh frozen plasma; Factor Ⅷ; Fibrinogen

成分输血是目前最经济有效的临床治疗手段，血小板制品对因血小板数量减少或功能异常而导致出血的患者具有较好的疗效，血细胞分离机单采血小板可以提高血小板的采集数量与质量、降低红细胞的浪费、减少献血人数，降低输血传播疾病的概率和输血反应率[1-3]。血细胞分离机是根据血细胞比重不同先分离出血浆再进一步分离出血小板，单采血小板献血者可以同时捐献血浆，血浆制备的冷沉淀主要含有Ⅷ因子和纤维蛋白原（FIB）。……