尹泉 肖文 赵超 王艳 谭晓林

摘 要 目的：探讨重建肠道微生态疗法对肠易激综合征患者T淋巴细胞亚群的影响。方法：选取100例肠易激综合征患者随机分为对照组和研究组各50例，对照组予以匹维溴铵对症治疗4周，研究组实施重建肠道微生态疗法治疗1周，于治疗前和治疗后1个月测定外周血T淋巴细胞亚群计数及比值。结果：治疗前两组T淋巴细胞亚群计数及比值无显著差异。治疗后，研究组的CD4+值、CD4+/CD8+值较前升高，CD8+值较前下降，且CD4+值显著高于对照组，CD8+值显著低于对照组，差异有统计学意义。结论：重建肠道微生态疗法可有效改善肠易激综合征患者的外周血T淋巴细胞亚群比例。

关键词 肠道微生态 肠易激综合征 T淋巴细胞

中图分类号：R975； R574.4 文献标志码：A 文章编号：1006-1533（2021）15-0021-03

Effect of intestinal microecotherapy on T lymphocyte subsets in patients with irritable bowel syndrome

YIN Quan， XIAO Wen， ZHAO Chao， WANG Yan， TAN Xiaolin

（Department of Gastroenterology， Boai Hospital of Zhongshan City， Zhongshan 528403， China）

ABSTRACT Objective： To investigate the effect of intestinal microecotherapy on T lymphocyte subsets in patients with irritable bowel syndrome. Methods： One hundred patients with irritable bowel syndrome were randomly divided into a control group and a study group with 50 cases each. The control group was treated with pinaverium bromide for four weeks， while the study group was treated with remodeling intestinal microecology for one week. The T lymphocyte subsets and their ratios were measured before and one month after treatment. Results： There were no significant differences in T lymphocyte subsets count and ratio between the two groups before treatment. After treatment， the CD4+ value and CD4+/CD8+ value increased and the CD8+ value decreased in the study group， and furthermore the CD4+ value was significantly higher and the CD8+ value was significantly lower in the study group than the control group （P<0.05）. Conclusion： Reconstruction of intestinal microecology therapy can effectively improve the proportion of T lymphocyte subsets in patients with irritable bowel syndrome.

KEY WORDS intestinal microecology； irritable bowel syndrome； T lymphocyte

腸易激综合征（irritable bowel syndrome， IBS）是一种临床常见的功能性疾病，主要表现为以腹痛或腹部不适伴有排便习惯改变和/或粪便异常。研究显示，IBS的发病机制与遗传因素、胃肠动力异常、脑肠轴调节异常以及肠道微生态等存在一定的关系[1]。肠道微生态失调可通过改变黏膜通透性、激活免疫反应等途径促进IBS的发生与进展[2-3]。IBS患者外周血T淋巴细胞亚群比例与健康人群存在差异[4]，予以益生菌治疗后可有效改善IBS患者临床症状及T淋巴细胞亚群的比例[5-6]。重建肠道微生态疗法是通过清洁肠道后短期内服用多种益生菌和益生元的综合治疗方案，该疗法不仅可以有效改善IBS患者的临床症状，还能显著提高其远期疗效[7]。……