多糖在皮肤领域的应用研究进展
2021-08-19刘玉超杨凯业刘光荣高爽陈毓许诺胡振林
刘玉超 杨凯业 刘光荣 高爽 陈毓 许诺 胡振林
[摘要]多糖是一类由单糖通过糖苷键连接而成的生物大分子。多糖具有高吸水性、易于成膜以及与肌肤接触的舒适感等物理特性和免疫调节、抗炎、抗氧化等生物活性,具有保湿、促进创伤愈合、治疗特应性皮炎、防紫外线损伤、治疗痤疮、延缓衰老、美白及皮肤屏障损伤修复功能,在皮肤领域具有极大的开发潜力和应用价值。
[关键词]多糖;应用;抗氧化;皮肤;生物活性
[中图分类号]R322.99 [文献标志码]A [文章编号]1008-6455(2021)07-0182-05
Progress in the Application of Polysaccharides in Skin
LIU Yu-chao1, YANG Kai-ye2, LIU Guang-rong2, GAO Shuang3, CHEN Yu1,XU Nuo1,HU Zhen-lin1
[1.College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325000,Zhejiang,China;2.Infinitus (China) Co., Ltd,Jiangmen 529156,Guangdong,China;3.School of Pharmaceutical sciences,Wenzhou Medical University, Wenzhou 325000,Zhejiang,China]
Abstract: Polysaccharides, were identified as multifunctional compounds linked by monosaccharides through glycosides.They have received significant research interest because of their physical characteristics such as high water absorption,easy film-forming and the comfortable touch as well as a wide variety of biological activities such as immunomodulatory , anti-inflammatory , anti-oxidant, etc. Polysaccharide could be beneficial for moisturizing, wound healing, treatment of atopic dermatitis,UV damage prevention,treatment of acne,anti-aging, whitening and skin barrier disruption repair, which has great potential and application value in skin.
Key words: polysaccharides;application;anti-oxidant;skin ;bioactivity
多糖廣泛存在于动物、植物和微生物中,是一类由单糖通过糖苷键以线性或支链的形式连接形成的聚合高分子碳水化合物,能够调控机体的多种生命活动功能。多糖来源广泛、无毒副作用,与肌肤具有良好的亲和力,因此,在皮肤领域具有广泛的应用。多糖分为均一多糖和不均一多糖两类,均一多糖由同一种单糖聚合而成,其结构相对紧密,大多可在皮肤表面形成锁水层,而部分β-葡聚糖类的均一多糖则具有抗原性,可以刺激机体的免疫调控。不均一多糖由两种及以上单糖组成,其结构更加复杂,部分可与蛋白结合形成蛋白聚糖来发挥免疫调控作用,总体上讲两者均具有吸水保湿性、抗氧化、抗炎及延缓衰老等生物学活性。本文就多糖在皮肤上的保护作用及近年来在皮肤领域的应用进行综述,以期为多糖外用于皮肤领域提供科学参考。
1 保湿
皮肤作为机体的第一道屏障,其最基本的功能就是防止水分的流失。……
