慢性湿疹患者在雾霾颗粒物的影响下应用复因冷敷修复乳+糠酸莫米松乳膏的疗效观察
2021-06-22王冰心曹海育李建英孙静
王冰心 曹海育 李建英 孙静
[摘要]目的:探讨复因冷敷修复乳联合糠酸莫米松乳膏在慢性湿疹患者中的疗效及对肌肤屏障功能的影响。方法:选取2017年6月-2020年5月笔者医院收治的200例慢性湿疹患者,随机分为单一组和联合组,每组100例,单一组采用糠酸莫米松乳膏单独治疗,联合组采用糠酸莫米松乳膏联合医用冷敷修复乳治疗,分析其临床治疗效果及对肌肤屏障功能的影响。 结果:单一组患者有效率为68%,联合组为94%(P<0.05);治疗后,联合组患者皮损面积、皮损瘙痒评分与靶皮损面积改善情况明显优于单一组;治疗4周后,两组EASI指数比较[(4.73±0.33)vs(2.12±0.27)]分,有显著性差异(P<0.05)。结论:复因冷敷修复乳联合糠酸莫米松乳膏能有效治疗基于受雾霾颗粒物影响的慢性湿疹,且安全性高,但由于大气颗粒会导致慢性湿疹患者的炎性反应更强烈及持久,故建议延长其治疗时间,提高皮肤修复能力,同时减少受损肌肤在雾霾天中的暴露时间。
[关键词]糠酸莫米松乳膏;复因冷敷修复乳;颗粒物;慢性湿疹
[中图分类号]R322.99 [文獻标志码]A [文章编号]1008-6455(2021)05-0104-03
Based on the Observation of the Curative Effect of the Application of Multi-cause Cold Dressing to Repair Milk + Mometasone Furoate Cream in Chronic Eczema Patients Under the Influence of Haze Particles
WANG Bing-xin, CAO Hai-yu, LI Jian-ying, SUN Jing
(Department of Dermatology, Shijiazhuang People's Hospital, Shijiazhuang 050000,Hebei,China)
Abstract: Objective To explore the therapeutic effect of reapplied cold emulsion combined with mometasone furoate cream on skin barrier function in patients with chronic eczema. Methods Take from June 2017 to May 2020, our hospital 200 cases of patients with chronic eczema, chronic eczema patients can be divided into single and joint group, each group of 100 cases were divided into using furoic acid in a single set of betamethasone cream therapy alone, the joint group furoic acid mo betamethasone joint medical ice cream repair cream treatment, analysis of the clinical treatment effect and the impact on the skin barrier function. Results The effective rate was 68% in the single group,and 94% in the combined group (P<0.05). After treatment, skin lesion area, skin pruritus score and target skin lesion area of the combined group were significantly improved compared with the single group. After 4 weeks of treatment, EASIindex of the two groups was compared [(4.73±0.33)vs(2.12±0.27)] (P<0.05). Conclusion Recombination of cold compress and mometasone furoate cream can effectively treat chronic eczema based on particulate matter in PMs,but due to atmospheric particles can lead to chronic eczema, inflammatory reaction in patients with more strong and durable, so suggest to prolong the treatment time, improve the skin repair ability, at the same time reduce the damaged skin exposure time in the fog day.
Key words: mometasone furoate cream; reapply cold compress to repair dressing;PMs;chronic eczema
湿疹是皮肤科多发病和常见病,临床主要表现为肥厚角化、干燥脱屑及瘙痒剧烈[1]。但其病因尚不清楚,大体分为外因和内因两个方面。临床上常用糖皮质激素药物对其进行治疗,疗效明显,但复发率高[2]。皮肤发挥着重要的屏障和保护功能,同时又首先与颗粒物广泛接触,其性质和功能的变化或损伤会对机体产生重要影响,而有研究表明医用护肤品可辅助治疗受损肌肤及湿疹[3],故此本文对医用冷敷修复乳联合糠酸莫米松乳膏治疗基于雾霾颗粒物影响下的慢性湿疹患者的临床效果进行分析,现报道如下。
1 资料和方法
1.1 一般資料:选择笔者医院皮肤科2017年6月-2020年5月收治的200例慢性湿疹患者,随机分为单一组和联合组,每组100例。联合组:100例,其中男61例,女39例,年龄22~64岁,平均(40±6.24)岁;病程4~23个月,平均(15.28±5.06)个月。单一组:100例,其中男41例,女59例,年龄23~63岁,平均(40.44±6.42)岁;病程4~21个月,平均(15.13±5.11)个月;两组患者在性别、年龄、病程等方面比较差异无统计学意义(P>0.05),具有可比性。……p>
