胡建军

摘要：目的：本文在反流性食道炎治疗方案的课题研究中，探究联合应用奥美拉唑与多潘立酮用药疗法的临床效果。方法：随机抽选我院2020年1月～2021年7月收录的82例反流性食道炎患者作为研究样本，依据计算机表法将患者均等分为奥美拉唑单一治疗方案的对照组、奥美拉唑+多潘立酮治疗方案的实验组，每组患者的人数相同，各为41例，对比两组患者临床治疗有效率、治疗前后反流≥5分钟的次数、最长反流时间等指标。结果：临床治疗有效率：实验组明显优于对照组（P<0.05），反流≥5分钟次数、最长反流时间：两组患者治疗前数值具有相似性（P>0.05），治疗后实验组数值下降幅度更大（P<0.05）。结论：反流性食道炎患者在制定治疗方案时，采用奥美拉唑联合多潘立酮用药策略，可以有效减少患者的反流次数，缩短患者的反流时间，取得最佳的临床治疗效果。

关键词：反流性食道炎;奥美拉唑;多潘立酮;临床疗效

Clinical efficacy of omeprazole combined with domperidone in the treatment of reflux esophagitis

Hu Jian-jun（Department 1，Zhengcheng Town Central Health Center，Pingyi County，Linyi 273311，Shandong，China）

Abstract：Objective To explore the clinical effect of omeprazole combined with domperidone in the treatment of reflux esophagitis.Methods 82 patients with reflux esophagitis in our hospital from January 2020 to July 2021 were randomly selected as research samples.According to the computer table method，the patients were equally divided into the control group of omeprazole single treatment regimen and the experimental group of omeprazole+domperidone treatment regimen.The number of patients in each group was the same，41 cases in each group.The clinical treatment efficiency，The Times of reflux≥5 min before and after treatment，the longest reflux time and other indicators were compared between the two groups.Results The effective rate of clinical treatment：the experimental group was significantly better than the control group（P<0.05），the number of reflux≥5 minutes，the longest reflux time：the two groups of patients before treatment had similar values（P>0.05），after treatment，the experimental group values decreased more significantly（P<0.05）.Conclusion Omeprazole combined with domperidone can effectively reduce the number of reflux，shorten the time of reflux，and achieve the best clinical treatment effect in patients with reflux esophagitis.

Key words：reflux esophagitis;Omeprazole;Domperidone;Clinical curative effect

反流性食道炎屬于临床上常见的消化系统病变，主要是指患者因酸反流或者碱反流损害患者的食管黏膜，临床主要以胃灼热、胸部疼痛、上腹部灼烧等症状表现为主，对患者的身心健康与生存质量造成影响，所以临床需要对疾病诊治引起重视，在患者病情确诊后，及时制定治疗策略。药物属于治疗反流性食道炎的主要方案，奥美拉唑属于质子泵抑制剂，虽然可以有效改善患者的病情，但是单一采用奥美拉唑用药方案无法取得理想疗效，所以提倡配合应用多潘立酮用药疗法，实现患者临床疗效的提高[1]。本文主要以我院近年来收录的82例反流性食道炎患者作为研究样本，探究奥美拉唑+多潘立酮治疗法的临床效果，从而为有关人士提供参考，报道进行如下整理。

1资料与方法