高伟超　颜宇博　王枫　曹艳秋　杜冠华

[摘要] 目的 觀察逐瘀生化汤对依沙吖啶中期引产的疗效。 方法 选择2018年2月至2019年2月在我院接受依沙吖啶中期引产的患者112例，随机分为观察组和对照组，每组各56例，对照组口服产后逐瘀胶囊，观察组口服逐瘀生化汤，比较两组引产成功率、清宫率、胎盘粘连率、产后出血量、产后出血时间及不良反应。 结果 观察组引产成功率为92.86%，高于对照组的89.29%，但差异无统计学意义（χ2=0.439，P>0.05）;观察组清宫率和胎盘粘连率分别为8.92%和3.57%，低于对照组的28.57%和16.07%，差异均有统计学意义（χ2=7.092，4.939，P<0.05）;观察组产后出血量和产后出血时间分别为（198.41±19.24）mL、（6.45±2.08）d，低于对照组的（302.23±25.38）mL和（8.61±2.56）d，差异均有统计学意义（P<0.05）;两组不良反应总发生率均为12.50%，未见严重不良反应。 结论 逐瘀生化汤可减少依沙吖啶中期引产的清宫率和胎盘粘连率，减少产后出血量和出血时间，无明显不良反应，值得临床推广。

[关键词] 中期引产;逐瘀生化汤;依沙吖啶;米非司酮

[中图分类号] R719.3          [文献标识码] B          [文章编号] 1673-9701（2021）04-0061-03

The curative effect of Zhuyu Shenghua Decoction for induction of labour in second trimester by ethacridine

GAO Weichao1   YAN Yubo1   WANG Feng1   CAO Yanqiu1   DU Guanhua2

1.Department of Obstetrics， Women and Children′s Hospital of Jinzhou City in Liaoning Province， Jinzhou   121000， China; 2.Department of Traditional Chinese Medicine， Women and Children′s Hospital of Jinzhou City in Liaoning Province， Jinzhou   121000， China

[Abstract] Objective To observe the curative effect of Zhuyu Shenghua Decoction for induction of labour in second trimester by ethacridine. Methods A total of 112 patients receiving induction of labour in second trimester by ethacridine in our hospital from February 2018 to February 2019 were randomly divided into the observation group（n=56） and the control group（n=56）. The control group was administrated Postpartum Zhuyu Capsule orally， while the observation group was administrated Zhuyu Shenghua Decoction orally. The success rate of labour induction， curettage rate， placental adhesion rate， postpartum hemorrhage volume， postpartum hemorrhage time and incidence of adverse reactions were compared between the two groups. Results The success rate of labour induction was 92.86% in the observation group， higher than 89.29% in the control group， but the difference was not statistically significant（χ2=0.439， P>0.05）. Curettage rate and placental adhesion rate in the observation group were 8.92% and 3.57%， respectively， lower than those in the control group（28.57% and 16.07%， respectively）， and the differences were statistically significant（χ2=7.092， 4.939， P<0.05）. The postpartum hemorrhage volume， postpartum hemorrhage time in the observation group were（198.41±19.24） mL and（6.45±2.08） days， respectively， which were lower than those in the control group（302.23±25.38） mL and（8.61±2.56） days， and the differences were statistically significant（P<0.05）. The total incidence of adverse reactions was 12.50% in both groups， and no serious adverse reactions were observed. Conclusion Zhuyu Shenghua Decoction for induction of labour in second trimester by ethacridine can reduce the curettage rate and placental adhesion rate， the amount and time of postpartum hemorrhage， without obvious adverse reactions， and is worthy of clinical promotion.

[Key words] Induction of labour in second trimester; Zhuyu Shenghua Decoction; Ethacridine; Mifepristone

孕中期引產指妊娠14～27周因母体疾病、防止先天性畸形儿及遗传病儿的出生、非意愿妊娠等不宜继续妊娠，需采用人工方法终止妊娠。随着产前诊断技术不断提高和社会因素影响，孕中期引产率呈上升趋势。依沙吖啶羊膜腔内注射引产手术因其操作简便、安全性好、成功率高、费用低，是目前临床上应用最广泛的中期妊娠引产方法[1]。尽管依沙吖啶引产操作简便、成功率高，但其产程长，容易发生胎盘粘连和残留，需行清宫术，产后出血量多、持续时间长，增加了受术者的痛苦。本研究在临床中不断总结经验，尝试在依沙吖啶引产时配合口服中药逐瘀生化汤，在减少中期引产并发症方面取得满意的效果，现报道如下。

1 资料与方法

1.1 一般资料

选择2018年2月至2019年2月在我院接受依沙吖啶羊膜腔内注射中期引产的患者112例，根据计算机简单随机化分组原则将其分为对照组（n=56）和观察组（n=56）。对照……