吴军榜

摘 要 目的：探討单硝酸异山梨酯缓释片联合复方丹参滴丸治疗老年不稳定型心绞痛的临床疗效。方法：选择2018年10月—2020年5月江西康宁医院收治的老年不稳定型心绞痛患者78例，按照随机数字表分为两组，每组39例。两组均接受常规基础治疗。对照组给予单硝酸异山梨酯片，30 mg/次，2次/d。观察组在对照组基础上联合使用复方丹参滴丸治疗，10粒/次，3次/d。两组均连续治疗1个月。观察心绞痛发作频率、每次心绞痛持续时间、ST段下移幅度和不良反应发生情况，评价疗效。结果：观察组干预后心绞痛发作频率较低，每次心绞痛持续时间较短，ST段下移幅度较小，均低于干预前和对照组（P<0.05）；观察组总有效率为97.44%（38/39），高于对照组的69.23%（27/39，P<0.05）；观察组不良反应总发生率为15.38%，低于对照组的20.51%（P>0.05）。结论：单硝酸异山梨酯缓释片联合复方丹参滴丸治疗老年不稳定型心绞痛，可以明显改善患者临床症状，且不会增加不良反应，应用价值较高。

关键词 老年不稳定型心绞痛；单硝酸异山梨酯缓释片；复方丹参滴丸；临床疗效

中图分类号：R541.4 文献标志码：A 文章编号：1006-1533（2021）04-0026-03

Clinical study of isosorbide mononitrate sustained release tablets combined with compound Danshen dripping pills in the treatment of unstable angina pectoris in the elderly patients

WU Junbang

（Geriatrics Department of Jiangxi Kangning Hospital， Nanchang 330103， China）

ABSTRACT Objective： To investigate the clinical efficacy of isosorbide mononitrate sustained release tablets combined with compound Danshen dripping pills in the treatment of unstable angina pectoris in the elderly patients. Methods： Seventyeight elderly patients with unstable angina pectoris admitted to Kangning Hospital of Jiangxi Province from October 2018 to May 2020 were selected and according to the random number table， divided into two groups with 39 cases in each group. Both groups received conventional basic treatment. The control group was given isosorbide mononitrate tablets， 30 mg/time， twice daily. The observation group was treated with compound Danshen dripping pills on the basis of the control group， 10 capsules/ time， 3 times/d. Both groups were treated continuously for 1 month. The frequency of angina pectoris， the duration of each angina pectoris， the amplitude of ST segment downward movement and the occurrence of adverse reactions were observed to evaluate the efficacy. Results： After intervention， the frequency of angina pectoris in the observation group was lower， the duration of angina pectoris was shorter， and the ST segment depression was smaller， all were lower than those before the intervention and the control group（P<0.05）； the total effective rate was 97.44%（38/39） in the observation group， which was higher than 69.23%（27/39） in the control group（P<0.05）； the total incidence of adverse reactions was 15.38% in the observation group， which was lower than 20.51% in the control group（P>0.05）. Conclusion： Isosorbide mononitrate sustained release tablets combined with compound Danshen dripping pills in the treatment of unstable angina pectoris in the elderly can significantly improve the clinical symptoms of patients without increasing adverse reactions， and has high application value.

KEY WORDS senile unstable angina pectoris； isosorbide mononitrate sustained release tablet； compound Danshen dripping pill； clinical efficacy

不稳定型心绞痛是一种急性冠脉综合征，多为老年患者，其本身敏感性较差，临床诊治易发生漏诊等情况，从而导致患者进展为心力衰竭，危及生命[1-2]。临床治疗主要是通过抗心绞痛药物治疗，笔者所在医院以单硝酸异山梨酯缓释片联合复方丹参滴丸进行干预，评价其疗效。

1 资料与方法

1.1 一般资料

选择2018年10月—2020年5月江西康宁医院收治的年龄>60周岁的老年不稳定型心绞痛患者78例，均符合诊断标准[3]。按照随机数字表法分为两组，每组39例。对……